Side Effects

Question 1

Ciclovirs.

Thymidine kinase inhibitors

Answer 1

Bone marrow suppression
Nausea Vomiting diarrhea (oral)
Crystaluria renal impairment
Neurotoxic
Fever 
Rash
Probenecid interaction

Question 2

Foscarnet HIV

Answer 2

Directly suppresses DNA RNA polymerase

Dose dependant nephrotoxicity very severe (acute tubular necrosis)

Tremors seizures (Electrolyte imbalance)
Hyperkalemia hypercalcemia &  lactic acidosis

Contra with pentamadine (nephrotoxicity)

Question 3

Entry inhibitors HIV

Answer 3

Myalgia
Arthralgia
Diarrhea
Hepatotoxic

Question 4

NRTIs

Answer 4

Zaduvudine
Bone marrow suppression
Acetaminophen toxicity
Hepatotoxic

Lamivudine entricitabine

Peripheral neuropathy
Pancreatitis

Question 5

NNRTIs

Answer 5

Less toxic than NRTIs
Rash
Inducer 3A4
LFT enzymes elevate AST LFT

Efavirenz
Nightmares

Question 6

Protease inhibitors

Answer 6

Nelfinavir : diarrhea

Atazanavir: Syndrome of disordered lipid and carbohydrates metabolism
Insulin resistance and central adiposity (rare)

Question 7

Integrase inhibitors

Answer 7

Headache

Fatigue

Question 8

Anti influ

Answer 8

Ataxia
Slurred speech
Dizziness
GI discomfort
Flu lijke symptoms

Question 9

Interferon

Answer 9

Contra in pregnancy
Flu like symptoms
Depression

Question 10

Ribavirin

Answer 10

Contra pregnancy
Dyspnea
Cough
Tiredness