SIADH Flashcards
1
Q
SIADH
- biochemistry
A
due to ectopic secretion of ADH by tumour or primary disorder in the pituitary
results in retention of water, hyponatraemia, serum hypo-osmolality and urine hyper-osmolality
2
Q
causes
A
paraneoplastic syndrome causing ectopic ADH secretion
cancer
lung disease
CNS
drugs
hypothyroid
subarachnoid haemorrhage
3
Q
which type of cancer is particuarly known for causing SIADH
A
SCLC
4
Q
which drugs cause SIADH
A
carbamepazine, chlorpromazine
5
Q
treatment
A
- underlying cause
- fluid restriction
- demeclocycline (ABx that reduces the responsiveness of collecting tubule to ADH)
- Tolvapton (vaspressor receptor antagonist)
6
Q
what hyponatraemic state would suggest SIADH
A
euvolaemia and hyponatraemia
