Shortness of Breath II (Johns) - W3 Flashcards

1
Q

Definition of dyspnea

A

abnormally uncomfortable awareness of breathing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Dyspnea on exertion (DOE) differential diagnosis

A

Differential Diagnosis

  • Congestive heart failure
  • Angina (angina equivalent)
  • Obstructive pulmonary disease
  • Pleural effusion
  • Anemia
  • Hypothyroid
  • Metabolic acidosis
  • Anxiety and hyperventilation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

4th ranked cause of death in US

most important lung disease in US

“disease has airflow limitation that is NOT FULLY REVERESIBLE”

A

Chronic obstructive pulmonary disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Key indicators of COPD

A
  • chronic cough
  • long smoking history
  • dyspnea - progressive, worse on exercise
  • chronic clear sputum production
  • weight loss
  • morning headache
  • cor pulmonale
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Physical exam for COPD

A
  • prolonged expiration
  • hyperinflation
  • hyperresonant to percussion
  • decreased breath sounds
  • wheezes
  • accessory muscles, pursed lips, cyanosis, enlarged liver, asterixis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How do you diagnose COPD?

A
  • chest x-ray
  • chest CT
  • pulmonary function tests
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What do you see on pulmonary function tests with COPD?

A
  • decreased FEV-1
  • Decreased FEV-1/FVC ratio
  • increased total lung capacity
  • absense of bronchodilator response
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What could be causing a low FEV1/FVC ratio

A
  • Bronchodilator
    • FEV1 increased = asthma
    • NO increase = COPD
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How should stable COPD be managed?

A

smoking cessation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What drugs can treat COPD?

A
  • Beta-2 agonist
  • Inhaled ipratropium (anticholinergics) - may show increased bronchidlation compared to beta agonists - inhibiting parasympaethic response. Prevent it happening and decrease mucous production.
  • Theophylline
  • Corticosteroids - may slow decline of FEV-1
  • supplemental oxygen
  • flu and pneumococcal vaccine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what antioxidant levels are often imbalanced in smokers/

A

Vitamin E levels low

Vitamin C, E and beta-carotene dietary intake low

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the 3 types of COPD

A

asthma

emphysema

bronchitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which population is asthma more prevalent in?

A

Puerto Rican

Multiple race

children

blacks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is seen and definited by the “definition of asthma”

A

Wheezing.

Cough.

Chest tightness.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the classic triad of symptoms?

A

Persistent wheeze.

Chronic cough.

Chronic dyspena.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is seen on tests for asthma?

A

Low FEV-1

Methacholine test - need much less inhaled to produce a + test and drop in FEV1 than a normla person does.

17
Q

What is the differential for asthma?

A

Children = foreign body, cystic fibrosis

Young/middle age = GERD, PE, bronchiectasis

Old age = COPD, heart failure

18
Q

Stepwise treatment for asthma.

A
  1. short acting beta agonist
  2. low dose ICS
  3. low does ICS + LABA
  4. medium dose ICS + LABA
  5. high dose ICS + LABA + omalizumab
  6. high dose ICS + LABA + oral corticosteroid + omalizumab
19
Q

What does omalizumab (Xolair) do?

A
  • Anti-IgE monoclonal antibody
  • Binds free IgE in the circulation
  • decreases receptors on basophils
  • given as injection sub-q
  • 7,000 to 30,000 per year
20
Q

What can immunotherapy be used for?

A

Dust mites, pollen, animal dander

Skin testing

21
Q

How does asthma differ from COPD?

A
  • Asthma is REVERSIBLE