shock, haemorrhage and wounds Flashcards
what is the definition of shock
A life-threatening, generalised form of acute circulatory failure with inadequate oxygen delivery and utilisation by cells
what are important features about shock
not a specific diagnosis
requires urgent intervention
what normally leads to shock
Decreased blood perfusion of tissues
Inadequate blood oxygen
Increased oxygen demand from tissues
- overlap
what are the clinical parameters of shock
heartrate + respiratory rate is up
blood pressure can start to drop
glasgow coma score -> concious level starts to drop
what are the biochemical markers of shock
blood tests that find elevated levels of lactate + urine output
what is lactate a sign of ?
someone who is hypoperfused
what is the SOFA score
related to scoring of sepsis
what are the four subcategories of shock
obstructive
distributive
cardiogenic
hypovolemic
what is distributive shock
failure of Vaso regulation -
problem with control of vasculature as peripheral
Severe peripheral vasodilation
blood circulation is dilated and uncontrolled
what is the main reason for distributive shock is
septic shock
briefly describe septic shock
the toxic effect of inflammatory response (large number of cytokines)
-> leads to many dilated blood vessels in peripheral system
what are two other types of distributive shocks
anaphylaxis and neurogenic
explain anaphylaxis
significant allergic reaction which triggers large release of biochemical mediators. for example histamine from mast cells
what does anaphylaxis lead to
gross peripheral vasodilation
explain what neurogenic shock is
spinal cord injury - problem with autonomic nervous system and vagal tone problems
explain hypovolaemic shock
reduction in your circulating blood volume -> loss of intravascular volume
what are the two subcategories of shock
haemorrhage
+
non haemorrhage
what are examples of haemorrhage causes
trauma
GI bleeding -> eg stomach ulcers
what are examples of non-haemorrhage bleeding
burns -> tissue loss / tissue damage
diabetes complications -> diabetic ketoacidosis which causes huge amounts of volume loss
explain cardiogenic shock
problems with the heart.
in particular the pump in the heart is failing
what can cause cardiogenic shock
heart attack
myocardial infarction
what are problems related to cardiogenic loss
arrhythmias -> irregular rhythms of the heart
mechanical problems -> valves of the heart are affected
explain obstructive shock
barriers to cardiac flow or filling
what are problems related to obstructive shock
pulmonary embolism (clots)in the vasculature of the lungs
cardiac tamponade
tension pneumothorax
what is cardiac tamponade
large amount of blood in the pericardial space (around the heart) -> restricts the pumping of the heart
what is tension pneumothorax
build up of air around the lungs - causes the lung to collapse
how would you treat distributive shock
fluid -> optimise circulatory status
vasopressers -> drugs that improve peripheral vasodilation
antibiotics
how do we treat hypovolaemic shock
fluid, giving blood
try to stop the loss of fluid in general
how do we treat cardiogenic shock
combination of different types of medicine
fluid
vasopressers
inotropes
cardiologist
what are inotropes
drugs that positively improve cardiac output
how do we treat obstructive shock
improve obstruction -> putting hole in chest to relieve pressure
preventing clots -> thrombolysis
what can make recognition of shock more complicated
people on medication
what is blood
majority plasma 55%
45% cells
explain in blood sample where plasma, WBC, RBC are ?