Shigella Flashcards
1
Q
Morphology
A
gram - O antigen non-motile
2
Q
Cultivation
A
Facultative Anaerobics
3
Q
Biochemical
A
Lactose - no gas production Acid stable ( need a lot to affect )
4
Q
name 4 shigella types
A
S. Dysenteriae (HUS) S. Flexneri S. Boydii S. Sonnei
5
Q
Virulence factors
A
Shiga toxin ( - 60 S ) Capillary damage
6
Q
Pathogenesis
A
M-cells invation ->Spread to epi/macrophages -> destruction epi/macro -> local inflam + bleeding ulcers
7
Q
Symptoms
A
(bloody)Diarrhoea fever few bloody mucous, purulent stool intracellular inflammation HUS!!! (Dysenteriae)
8
Q
Diagnosis - species ID - serological ID - virulence genes
A
- MALDI-TOF - agglutination test on O antigen - PCR
9
Q
Therapy
A
Ciprofloxacin (ampicillin, cephalosporins)
