SGD - Myocardial Infarction

Question 1

The first way to block cholesterol synthesis is by:

A. Decreasing the production of Acetyl-CoA
B. Interrupting the conversion of HMG-CoA to mevalonate
C. Blocking the enzyme acetyl CoA carboxylase
D. All of the above

Answer 1

B. Interrupting the conversion of HMG-CoA to mevalonate

Question 2

Stable symptoms of ischemia such as mild and short term anginal discomfort is brought about by:

A. The presence of severe coronary obstruction
B. Narrowing of the vessel lumen
C. Rupture of atherosclerotic plaque
D. Thrombus formation

Answer 2

B. Narrowing of the vessel lumen

Question 3

What is the most common type of angina?

A. Stable
B. Unstable
C. Prinzmetal
D. Variant

Answer 3

A. Stable

Question 4

During Acute MI, once the myocardium becomes depleted of ATP after a shift into anaerobic glycolysis, this could result into

A. Accumulation of glycogen in the myocardium
B. Development of severe alkalosis
C. Accumulation of lactic acid
D. All of the above

Answer 4

C. Accumulation of lactic acid

Question 5

A major feature of elevated cardiovascular risk in patients with diabetes mellitus 2 relates to the abnormal lipoprotein profile associated with insulin resistance

A. True
B. False

Answer 5

A. True

Question 6

Aspirin acts by irreversibly inactivating platelet, the enzyme

A. Cyclo-oxygenase (COX)-1
B. Lipoxygenase
C. Phospholipase A2
D. Phospholipase A1

Answer 6

A. Cyclo-oxygenase (COX)-1

Question 7

The above reaction will stop the synthesis of a known vasoconstrictor and potent platelet aggregator which is:

A. Lipoxins
B. Thromboxane A2
C. Prostaglandin D2
D. Leukotrienes

Answer 7

B. Thromboxane A2

Question 8

This enzyme increases within 3-12 hours of onset of chest pain, reach peak values within 24 hours, and return to baseline after 48-72 hours.

A. Troponin I
B. CK-MB
C. Troponin T
D. Lactate Dehydrogenase

Answer 8

B. CK-MB

Question 9

Serum levels increase within 3-12 hours from the onset of chest pain, peak at 24-48 hours, and return to baseline over 5-14 days after acute MI.

A. Troponin I
B. CK-MB
C. LDH
D. Myoglobin

Answer 9

A. Troponin I

Question 10

The initiation and evolution of an atherosclerotic plaque takes place

A. within 24 hours
B. over a week
C. over a month
D. over many years

Answer 10

D. over many years