Sexually Transmitted Bacterial Diseases

Question 1

Gonnorrhea (Neisseria Gonorrhoeae)

Answer 1

• P2P: sexually transmitted + perinatal transmission
• aerobic, bean-shaped, gram(-) diplococcus
• pili with IgA protease: attach to transitional epithelium of columnar/transitional epithelium of urogenital tract
• acute inflammtory response-abscecess
• Men: purulent urethral discharge, dysuria, orchitis, epididymitis (may cause infertility)
• Women: 50% asymptomatic, endocervicitis, vaginal discharge/bleeding, urethritis with dysuria, chronic salpingitis, pelvic inflammatory disease (infertility if tubes swell/blocked with pus), endometritis, Fitz-Hugh-Curtis Syndrome (healing fibrous attachement liver–parietal peritoneum)

Question 2

Chancroid (Haemophilus ducreyi)

Answer 2

• gram(-) bacillus, histology looks like school of fish
• P2P: sexually
• Chancroid: leading cause of genital ulcers in 3rd world countries (facilitate spread of HIV)
• opportunistic: enters through breaks in skin
• painful, unilateral, suppurative, inguinal lymphadenitis (bubo)
• erythromycin: effective treatment

Question 3

Granuloma Inguinale (Calymmatobacterium granulomatis)

Answer 3

• small, encapsulated, nonmotile, gram(-) bacillus
• Granuloma inguinale: chronic, superficial ulceration of genitalia and inguinal and perianal regions
• lesion is granulation tissue–macrophages, plasma cells, neutrophils and lymphhocytes
• Donovan bodies: interspersed macrophages containing bacteria
• genital elephantiasis: obstruction of lymphatics–thickening of skin and edema (NO BUENO)