Sexuality Flashcards

1
Q

What are the three steroid hormones in estrogen?

A

estradiol
estrone
estriol

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2
Q

Pharmacological uses of estrogen?

A

hormone replacement
birth control
treatment of some types of cancers

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3
Q

MOA of conjugated estrogen?

A

binds to estrogen receptors

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4
Q

Therapeutic effects of conjugated estrogen?

A

treat hypogonadism
treat sxs of menopause
palliative treatment of hormone cancers
feminizing hormone therapy

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5
Q

Contraindications for conjugated estrogen?

A

hx of many female cancers
hx of hepatic cancers
pregnancy
lipid disorders

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6
Q

MOA of medroxyprogesterone?

A

prevents surge of Luteinizing Hormone; prevent ovulation
maintains endometrium

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7
Q

Therapeutic effects of medoxyprogesterone?

A

decreased bleeding
prevent ovulation
treat endometrial cancers
used with IVF for endometrial growth

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8
Q

Contraindications for medroxyprogesterone?

A

clotting disorders
pregnancy
hepatic impairment
female cancers

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9
Q

What is estradiol and norethindrone a combination of?

A

estrogen + progestin combination

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10
Q

Therapeutic effects of estradiol and norethindrone?

A

prevent contraception
acne treatment
endometriosis treatment
menstrual bleeding/pain regulation

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11
Q

Contraindications for estradiol and norethindrone?

A

breast cancer,
hx of stroke
depression
pregnancy

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12
Q

What two things decrease effectiveness of OC’s?

A

anticonvulsants
antibiotics

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13
Q

Benefits of testosterone?

A

matures male reproductive system
secondary sex characteristics
increase muscle mass
increase erythropoietin and RBC’s

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14
Q

MOA of testosterone?

A

replaces or enhances male hormone

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15
Q

Therapeutic effects of testosterone?

A

androgen replacement therapy
hypogonadism
palliative txt of breast cancer
treats muscle wasting (AIDS)
masculizing hormone therapy

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16
Q

Contraindications for testosterone?

A

male breast cancers
prostate cancers
DM
pregnancy

17
Q

MOA of sildenafil?

A

enhances nitric oxide
induced vasodilation in the penis and pulmonary system

18
Q

Therapeutic effects of sildenafil?

A

enhances erection
improves oxygenation
treatment of Raynaud’s (off-label)

19
Q

Contraindications for sildenafil?

A

cardiovascular disease
kidney/liver disease
patients who require nitrate/nitrite therapy

20
Q

What are 2 types of BPH MOA?

A

Alpha 1 adrenergic blockers - relaxes smooth muscle
5-alpha reductase inhibitors - shrinks epithelial tissue

21
Q

MOA of finasteride?

A

inhibits 5-alpha reductase decreasing T production
shrinks prostate

22
Q

Therapeutic effects of finasteride?

A

BPH relief
male pattern hair loss