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Pharmacology 2700 > Psychosis > Flashcards

Psychosis Flashcards

1
Q

What is lithium carbonate used for?

A

mood stabilization

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2
Q

What is MOA of lithium?

A

not completely known
increases serotonin synthesis

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3
Q

Lithium side effects?

A

lethargy
dizziness
confusion
tremors
N/V
polyuria/nocturia

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4
Q

What can increase lithium toxicity?

A

NSAIDS
exercise
haloperidol - increased risk of neurotoxicity

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5
Q

What is etiology of schizophrenia?

A

genetics
environment
abnormal dopaminergic pathways

NOT COMPLETELY KNOWN

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6
Q

“positive” sxs of schizophrenia? (surplus, more elevated)

A

hallucinations
delusions
paranoia
agitation

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7
Q

“negative” sxs schizophrenia? (taking away)

A

withdrawal
lack of ability to perform ADLs
poor judgement

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8
Q

cognitive sxs schizophrenia?

A

deficits in long term memory
difficulty following instructions
difficulty completing tasks
inability to focus

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9
Q

Are extrapyramidal symptoms (EPS) reversible?

A

No

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10
Q

What type of drug is haloperidol?

A

dopamine antagonist
antipsychotic; non phenothiazine

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11
Q

MOA of haloperidol?

A

depresses cerebral cortex, hypothalamus, and limbic system

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12
Q

Side effects of haloperidol?

A

weight gain
anemia
anticholinergic
respiratory depression

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13
Q

Contraindications and cautions of haloperidol?

A

parkinson’s
seizure disorders
alcoholism
CNS depression
lactation
dementia-related psychosis

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14
Q

MOA of risperidone?

A

block various dopamine

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15
Q

Side effects of risperidone?

A

“whisper”idone want to whisper about side effects
elevated prolactin levels: nipple excretions, gynecomastia, menstrual irregularities

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16
Q

MOA of quetiapine?

A

antagonizes dopamine and serotonin receptors

17
Q

Side effects of quetiapine?

A

lens changes (PINE is difficult to see up high)
leukopenia

18
Q

MOA of ziprasidone?

A

antagonizes dopamine and serotonin receptors; inhibits reuptake

19
Q

Side effects of ziprasidone?

A

dysrhythmias and QT prolongations
(do not give to heart disease patients)

20
Q

MOA of aripiprazole?

A

partial dopamine agonist

21
Q

Side effects of aripiprazole?

A

increased risk of suicide

22
Q

What are cautions for atypical drugs?

A

do not give to dementia-related psychosis

23
Q

What are first generations psychosis drugs?

A

haloperidol

24
Q

What are atypical (2nd and 3rd) generation psychosis drugs?

A

aripiprazole
risperidone
quetiapine
ziprasidone

25
Q

Dopamine antagonist psychosis drugs?

A

resperidone
quetiapine
ziprasidone

26
Q

Dopamine system stablizer psychosis drug?

A

aripiprazole

27
Q

Nonphenothiazine, dopamine antagonist psychosis drug?

A

haloperidol

Pharmacology 2700 (2 decks)

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