Sexual Medicine Flashcards
Major arterial supply to penis
pudendal artery
Mechanism of erections
Release of _____
____ in cAMP & cGMP
____ in intracellular Ca++
smooth muscle ____
Release of NO
Increases cAMP & cGMP
Decreases Ca++
Smooth muscle relaxation
Duplex penile doppler u/s
Normal values
Peak systolic > ___
End diastolic < ___
Peak systolic > 30
End diastolic < 5
Venous leak ED leads to ____ end diastolic velocities
HIGH (>5)
PDE-5 mechanism
Inhibits degradation of ____
inhibits cGMP degradation into GMP
Take Viagra (sildenafil) ____ food
Take Cialis (tadalafil) ___ food
Viagra –> NO FOOD
Cialis–> okay for food
Duration of action for Cialis (tadalafil)
36 hrs
Duration of active for Viagra/Levitra (sildenafil/vardenafil)
4-6 hrs
Protease inhibitors increase the _____ of PDE-5is
concentration (2-3x as potent)
Separate alpha blocker & PDE-5i by ___ hrs to avoid cumulative hypotension
4 hrs
PDE-5i side effects
Headache Facial flushing GERD Nasal congestion Diplopia, blurred vision, chromatopsia
Trimix components & mechanisms
___ : cAMP activator
___ : PDE inhibitor
___ : alpha blocker
PGE-1 : cAMP activator
Papaverine : PDE inhibitor
Phentolamine : alpha blocker
Psych med that is a contrindication to Trimix
MAOI
cannot give phenylephrine to reverse possible priapism*
Pain with ICIs is due to ___ hypersensitivity
PGE-1
Intra-urethral suppositories can cause ___ bleeding, priapism, and penile pain
urethral
