Sex linked

Question 1

states that one x chromosome in each cell is randomly inactivated early in the embryonic development of females

ensures females who habe two copies of X chromosome will produce x linked gene products in quantities similar to those produced in males

Answer 1

lyon hypothesis

(proof of hypothesis - calico cats, x linked ocular albinism, barr bodies)

dosage compensation

Question 2

x linked dominant

and

x linked recessive

Answer 2

x linked dominant - 50% of sons affected and 50% of daughter affected

x linked recessive - 50% of sons affected and 50% of daughters are heterzygous carriers

Question 3

fragile x syndrome

Answer 3

most common inherited cause of mental retardation

long face and large ears - weird face

much higher in males

INHERITED - down syndrome is chromosome abnormality

X - affected x chromosomes exhbit gaps near the tip of the long arm

Question 4

when permutations tend to become larger in succesive generation

Answer 4

sherman paradox

seen in fragile X

Question 5

progressive degeneration of the pigment layer of the retina, cardiac conduction abnormalites, ataxia, deafness, dementia

mitochondrial disease

Answer 5

kearns sayer syndrome

mito*

Question 6

hemophilia a

Answer 6

x linked recessive