Sex endocrinopathies Flashcards
Most common causes of hyperestrinism in the dog?
cystic ovaries granulosa cell tumors (ovaries) sertoli cell tumors (testicles) estrogen treatment (eating owners estrogen lotion)
hyperestrinism clinical signs?
vulvar edema +/- discharge alopecia of caudal trunk and perineum epidermal hyperpigmentation nipple enlargement attractive to other dogs
hyperestrinism treatment?
OHE or stop estrogen drugs
estrogen myelotoxicosis
exogenous estrogen
major life threatening complication that causes anemia, leukopenia, and thrombocytopenia
pale petechia v. bright red petechia?
pale - anemic and low PLT
bright red- normal PCV with low PLT
prognosis and treatment of myelotoxicosis (pancytopenia)?
bone marrow biopsy for prognosis
if no precursor cells - grave
hypoplastic is a lot better than aplastic
treatment - blood products, neupogen (increase WBCs) and epogen (increase RBCs)
remove estrogen source
3 cell types of testicular tumors?
Sertoli (nourish developing sperm) - metastasis and feminization
Seminoma (gamete production) - metastasis and feminization
Interstitial (leydig) (create testosterone) - mets and fem rare (most benign)
sertoli cell tumor (SCT) incidence?
3-20 years old
8-9 is avg
SCT site of involvement
usually unilateral (right cryptorchid most common!) 30-40% extrascrotal (inguinal or abdominal)
SCT clinical signs
testicular enlargement
feminization most common with abdominal > inguinal»_space; scrotal
feminization clinical signs?
atrophy of other testicle alopecia gynecomastia pendulous prepuce prostatic changes- metaplasia, infection tend to attract other male dogs decreased libido lethargy
common SCT?
carcinoma, treat aggressively
Pyometra in dog v. cat
cat takes longer to show clinical signs
Causes of uteromegaly?
pregnancy cystic endometrial hyperplasia (hyperestrinism) pyometra hydrometra mucometra tumors torsion
Pyometra etiology?
hormone influence.
hyperplasi and secretion of endometrial glands because progesterone
Pyometra - predisposing drugs?
megestrol acetate
progesterone
Pyometra clinical signs?
4-12 weeks post estrus PD/PU vaginal discharge (50%) anorexia depression abdominal distention
If Pyometra case comes in very sick, what are you worried about?
AKI and renal shutdown
Systemic effects of Pyometra?
anemia cario arrhythmias impaired renal fx sepsis (E. coli) toxemia
E. coli endotoxins block ADH where?
At receptor site of collecting duct
Pyometra dx?
history and clinical findings
hematology with leukocytosis
abdominal rads/US
Pyometra rx?
IV fluids
Antibiotics for gram - bacteria
OHE (check urine output post op)
med alternative? PGF2a; will get pyo again eventually
Always rule out pyo in ANY sick ________ dog and cat.
intact female
NEVER LET THE SUN SET ON _______.
A SICK PYO
