Session 9.1: Pharmodynamics 1

Question 1

what is pharmodynamics and what can it help with

Answer 1

what a drug does to body when binds to receptor and the effects - dose and response

Question 2

where is most molecular targets for drugs targeted

Answer 2

GCPR (around 800 in genome)

• diverse
• activates variety of intracellular signalling pathways

Question 3

what are some examples of therapeutic ligands targeting GPCR

Answer 3

bisoprolol fumerate
salbutamol
co-codamol

Question 4

what is an example of a drug that doesnt bind to GPCR

Answer 4

atorvastatin

Question 5

what does bisoprolol do and where does it bind

Answer 5

treats hypertension/angina by acting as Beta1AR - selective antagonist

Question 6

what does salbutamol do and where does it bind

Answer 6

treats asthma by acting as Beta2AR - selective agonist

Question 7

what does co-codamol do and where does it bind

Answer 7

treats analgesia by acting as U-opioid receptor agonist

Question 8

what does atorvastatin do and where does it bind

Answer 8

treats dyslipidemia by acting as HMG-CoA reductase inhibitor

Question 9

what is a ligand

Answer 9

something that binds to a receptor - drug, hormone, neurotransmitter

Question 10

what the drug is able to do is determined by

Answer 10

the concentration of drug molecules aroudn the reeptors

Question 11

molarity =

Answer 11

mass/molecular weight …in l (make sure l not ml)

Question 12

picomolar

Answer 12

x10-12M

Question 13

in one litre of solvent how many moles of the drug and there in comparison to water molecules

Answer 13

1 in 50

Question 14

1 mol of substances contain

Answer 14

6x10^23 molecules

Question 15

no of molecules in litre

Answer 15

moles x 6 x10^23

Question 16

drug concentrations should be in terms of

Answer 16

molarity