Session 9- immunocompromised host Flashcards
What causes secondary immunodeficiency?
A treatment or underlying disease which either reduces production/ function of immune components or increases the loss/ catabolism.
What type of infections suggest an immunodeficiency?
SPUR Severe Persistent Unusual Recurrent
What is the weakness of the ‘10 warning signs’ of primary immunodeficiency?
Lots of them are infections and PID doesn’t always present like this; can present as autoimmunity, malignancies or inflammatory conditions
Which malignancy is most common in PID?
lymphoma
Most PID’s are caused by defects in ___?
antibodies
What is Bruton’s Disease?
What is it caused by?
What treatment is given?
(XLA, X linked agammaglobuliaemia)
X linked recessive condition which fails to produce mature B cells, causing antibody deficiency and recurrent infections
Immunoglobulin replacement therapy (IRT)
What is CVID?
How is it treated?
Common variable immunodeficiency, PID categoried by low antibody levels and recurrent infections.
Lifelong IVIG therapy
(intravenous immunoglobulin)
SCID is caused by defects in which cells?
Which person famously suffered this condition?
(SEVERE combined immunodeficiency)
T cells and B cells
which cause an impaired antibody response
David Vetter
Name 2 conditions caused by defects in phaogocytic cells
- Chronic granulomatous disease (no respiratory burst)
- Chediak Hegashi Syndrome (no fusion of lysosome and phagosome)
How does CGD often present?
- pulmonary aspergillosis
- skin abscesses
What does the age of symptom onset indicate about the cause of immunodeficiency?
Under 6 months- T cell/ phagocyte defect
6 months plus; B-cell/ Ab/ phagocyte defect
5 years plus- B cell/ Ab/ complement defect or secondary ID
Why can’t you detect an antibody defect in children under 6 months?
Have protection from mother’s antibodies through breast milk
which vaccines cannot be given in PID’s?
live vaccines like MMR
What type of immunoglobulin therapy is given to children?
SCIG therapy
sub cutaneous
Why should radiation exposure be especially limited in PID’s?
Patients are more susceptible to malignancies
