Session 5 - Functions of the stomach Flashcards
What are the basic functions of the stomach?
- Receive food (short term storage)
- Disrupt food (contractions)
- Continue digestion (mainly proteins)
- Disinfect
What is the basic structure of the stomach?
Superior > Inferior
- Oesophageal entry
- Cardia
- Fundus
- Body
- Antrum
- Pylorus
What are the characteristics of the stomach?
- Simple columnar epithelium
- Mucosa/submucosa in folds - Rugae
- Gastric pits
What are the gastric pits and their functions?
Epithelial pits, containing specialised cells.
- Mucous cells
- Parietal cells
- chief cells
- G cells
Describe the muscle layers of the stomach.
Inner oblique
Middle circular
Outer longitudinal
How does the shape of the stomach affect the chyme?
Larger (proximal) to smaller (distal)
Separates the contents - lumps left behind.
How is food moved through the stomach?
Strong peristalsis.
Proximal to distal. (every 20 seconds)
Liquid chyme ejected into duodenum 3 times per minute.
What are the orad and caudad regions of the stomach?
Orad - upper stomach
Caudad - Lower stomach
How does the stomach expand when food is eaten?
- Vagally mediated relaxation of orad stomach (when food sensed in oesophagus)
- Rugae can expand
Why is it important for the stomach to extend when food is eaten?
Prevents an increase in intra-gastric pressure, which prevents reflux of stomach contents during swallowing.
Which cells secrete which products in the stomach?
Parietal cell = HCL + intrinsic factor G Cell = Gastrin Enterochromaffin like cell = Histamine Chief cell = Pepsinogen D Cell = Somatostatin Mucous cells = Mucus
Which products are mostly secreted in the cardia?
Mucus secretions
What is mostly secreted by the fundus/body?
Mucus, HCL, pepsinogen.
Which substances are secreted at the pylorus?
Gastrin, somatostatin
Which hormones control HCl production?
Parietal cell Stimulated by: -Gastrin -Histamine -ACh
Signals from which nerve to the stomach would increase HCl secretion?
Parasympathetic - Vagus.
What stimulates G-cells at the stomach to secrete gastrin?
Presence of peptides/amino acids in stomach lumen.
Vagal stimualtion (ACh, Gastrin-releasing peptide GRP)
How is HCl secretion inhibited in the stomach?
- pH drop when food leaves stomach (food is buffer)
- Low pH activates D cells - secrete somatostatin
- Somatostatin inhibits G cells. (and enterochromaffin cells) less gastrin, less histamine)
- thus less H+, less gastrin - Stomach distension reduces, thus reduced vagal activity.
What are the three phases of digestion?
- Cephalic
- Gastric
- Intestinal
What is cephalic digestion?
a) Parasympathetic stimuli (smelling/ tasting/ chewing/ swallowing) (30% of HCl)
- Causes direct stimulation of parietal cells by vagus.
- Stimulation of G cells by vagus.
b) Anticipating food = increases gastric motility slightly.
How does gastric digestion cause digestion of food?
60% total HCl
- Distension of stomach - vagal stimulation
=stimulate parietal / G cells
-Presence of amino acids / peptides
=stimulate G cells
-Food acts as buffer
=removes inhibition on gastrin production
What role does the enteric nervous system and gastrin have on the stomach?
Cause strong smooth muscle contractions.