Session 4 Reproduction Flashcards

1
Q

What is the scrotum and it’s embryological origin?

A

Fibromuscular cutaneous sac which is an extension of the perineum.
Origin from the genital swellings, these swelling will fuse to form the scrotal raphe.

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2
Q

What is contained in the scrotum?

A

Spermatic cord, epididymis & the testis

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3
Q

What are the layers of the scrotum ?

A
  1. Skin
  2. Dartos muscle and fascia
  3. External spermatic fascia
  4. Cremaster muscle and fascia
  5. Internal spermatic fascia
  6. Tunica vaginalis (parietal and visceral layer)
  7. Testis ( tunica albuginea)
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4
Q

What is the function of the dartos muscle ?

A

This is SMC which will contract to wrinkle the skin (note it is situated directly below the skin of the scrotum). This will decrease the surface area to decrease heat loss in its role in regulating spermatogenesis.

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5
Q

What is the origin of the cremaster muscle and what is its role in the scrotum?

A

The cremaster muscle comes from the internal oblique.
It is a skeletal muscle
It’s role is in elevating the testis to also regulate temperature of the testis (when elevated closer to the body and therefore warmer if needed)

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6
Q

What is the lymphatic drainage of the scrotum ?

A

They drain into the superficial inguinal lymph nodes .
These are palpable on the inferior border of the inguinal ligament on the medial aspect of the thigh. There are horizontal and vertical lymph nodes here.

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7
Q

What is a variocele ?

A

Dilation of the veins in the region of the scrotum. (The pampiniform plexus). This will then cause the scrotum to be enlarged and feel like a bag of worms.

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8
Q

Where is a variocele most likely to occur?

A

Most likely to occur on the left hand side as a result of the fact the left testicular vein is on longer, drains into the smaller left renal vein, and enters this vein at a perpendicular angle.

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9
Q

What is a hydrocoele ?

A

This is where there is fluid (serous) in the tunica vaginalis. This is often due to a failure of the closure of the processus vaginalis, or there is some infection of this region.

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10
Q

What is a haematocoele?

A

This is where there is blood in the tunica vaginalis and this is due to trauma (most commonly) or also due to infection.

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11
Q

What kind of hernia can appear in the scrotum ?

A

Indirect inguinal hernia.
This is where the contents of the abdomen can pass through the inguinal canal through the deep and superficial ring to emerge medially to the inferior epigastric vessels to then descend in to the scrotum, the extent of the descent is enabled by the amount of processus vaginalis still present and patent.

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12
Q

What are the common causes of scrotal enlargement ?

A
Indirect inguinal hernia
Haemaotcoele 
Hydrocoele 
Variocoele 
Epididymitis
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13
Q

What is transillumination and why is it important ?

A

Processor of shining light on the scrotum.
Differentiate between solid and also liquid.
Also between blood and serous fluid.

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14
Q

What are the effects of an enlarged scotrum?

A

Pain, distension of the scrotum, infertility, inability to get erect, systemic features ( fever, tiredness, lethargy).

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15
Q

Where does the spermatic cord run from and to?

A

It originates from the deep inguinal ring and will pass through the inguinal canal to end finally at the posterior border of the testis.

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16
Q

What are the coverings of the spermatic cord?

A

External spermatic fascia ( from aponeurosis of ext. oblique)
Cremasteric fascia and muscle (from internal oblique)
Internal spermatic fascia ( from the t. Fascia)

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17
Q

What are the contents of the spermatic cord ?

A

Testicular artery, cremasteric artery, artery to the vas deferens
Pampiniform plexus
Lymphatics
Genital branch of the genitofemoral nerve (lumbar plexus)
Vas deferens
Remnants of the processus vaginalis

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18
Q

What is the function of the pampiniform plexus?

A

It wraps around the testicular artery to act as a heat exchanger to ensure there is no elevated rise in temperature which would impair gametogenesis.

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19
Q

Where does the pampiniform plexus drain into ?

A

The right hand side will drain into the right testicular vein and then into IVC.
The left hand side -> left testicular vein -> left renal vein -> IVC.

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20
Q

What is the trajectory of the vas deferens?

A

It will originate from the tail of the epididymis, travels through inguinal canal, come up the lateral pelvic floor close to the ischial spine and turn medially to pass between the bladder and the urethra. It joins the duct of the seminal vesicle to become the ejaculatory duct.

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21
Q

What is testicular torsion?

A

This is where the testicle has twisted toward the midline of the body and in turn has twisted the spermatic cord, which then causes the blood supply to the testis to be cut off, and therefore there is Ischaemia and necrosis of the testis.

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22
Q

What are the symptoms of testicular torsion ?

A

Sudden and severe onset of pain.
Mild systemic features also present.
Nausea and vomiting.

It is often preceeded by excercise or physical activity.

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23
Q

Nerves from which branch innervate the posterior, inferior and anterior scrotum?

A

Anterior -> from the lumbar plexus

Posterior and inferior -> from the sacral plexus

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24
Q

What is the lymphatic drainage of the testis?

A

The paraaortic and lumbar nodes (located at L1)

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25
Q

What is the arterial supply of the testis ?

A

The testicular artery, artery from the abdominal aorta directly below the origin of the Renal artery.

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26
Q

What is the tunica albigunea?

A

Tough outer covering of fibrous material which will also line the inner aspect of the testis forming septa which Seperate the testis into functional lobules.

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27
Q

What is located on the posterolateral aspect of the testis?

A

The epididymis

28
Q

What is cryptoorchididsm ?

A

This is where there is failure of the descent of the gonads which are usually stuck somewhere along there normal trajectory. This is commonly due to prematurity, as complete descent is completed by 9 months.
This is different from ectopia of the testis, where testis are in a different region (where it shouldn’t)

29
Q

What tumours are common in the testis?

A

Germ cell tumours.
Often present as limb, with small amounts of pain .
Often overlooked, common in children.

30
Q

Comment on the histology of the vas deferens ?

A

Pseudostratified columnar ep. With some stereocilia.
Thick straight, fibromuscular tube.
Three muscular layers : ( longitudinal, circular and longitudinal)
Enable powerful ejaculation.

31
Q

Comment on the histology of the seminiferous tubules?

A

Outer side : perilobular connective tissue & collagen
Sertoli cells extend into the lumen of the tube & embedded in these cells are the germ cells which develop into the tube.
At the end of the tube Sertoli cells will form a Sertoli plug at the start of the straight tubules.
Sertoli cells act as a blood testis barrier to protect the body from new cells and vice versa. They also have a nutritive role.

32
Q

What are type A & type B speramatogonium ?

A

Type A : pale, these are cells Undergoing mitotic divisions.
Type b : dark -> becoming the future spermocyte

33
Q

Comment on the histology of the rete testis?

A

Anastomisng channel of tubules which will become the efferent ductile. It is lined with simple cuboidal epithelium.

34
Q

Comment on the histology of the efferent ductules?

A

Cuboidal cells - absorb the fluid produced from the seminiferous tubules
Cilliated cells - move the sperm along
Outer surface has contractile tissue

35
Q

Comment on the histology of the epidydimis ?

A

Single coiled tube (4-6m long). Storage site for the sperm.
Pseudostratified Columnar ep, which have sterocillia on apical membrane (absorptive function) and to move the sperm along.
Outer cells are contractile the relative proportion of these cells increase as you get to the tail.

36
Q

Describe what makes up the penis?

A

Three tube like structures :
Paired corpus cavernosum placed dorsally
Origin from the crus of the penis, (the ischiopubic rami)
Single corpus sponigiousum placed ventrally
Origin from the bulb of the penis

The end part of the penis is called the glans penis.

37
Q

What region of the penis is responsible for the erection?

A

Blood will fill the corpus cavernosum and this will erect the penis.

38
Q

Where does the urethra run in the penis?

A

Urethra runs in the corpus spongiosum.

39
Q

Comment on the layers of the penis?

A
Skin 
Dartos fascia (superficial) 
Bucks fascia (deep) plays an important role in the keeping the penis adhered to the body as it is continous with muscles in the perineum.
40
Q

Which two muscles in the perineum are important in the maintenance of an erection?

A

Ischiocavernosus -> this is attached from the ischium and the pubis to the crus of the penis. When it contracts it will compress the crus of the penis, limiting the blood from moving backward.
Bulbiospongiosum -> around the bulb and proximal shaft of penis (ventrally) this helps maintain an erection.

41
Q

Which muscle is important in expelling urine from the urethra?

A

Bulbiospongiosus.

42
Q

Which ligaments are attached to the penis?

A

Fundiform ligament - this arises from the midline of the linea alba (scarpa fascia) and will come around the bulb of the penis laterally and inferiorly to form a sling before continuing as dartos fascia in the scrotum.
Suspensory ligament of the penis - this attaches the penis to the pubic symphysis, this will help to ensure maintenance of erection.

43
Q

What is a penile fracture?

A

This is where the outer tunica albigunea of the corpus cavernosum is broken, and the blood can leak out.
Symptoms : popping sound, pain, flaccidity & heamtoma.

44
Q

Comment on the Neurovasculature of the penis?

A

Artery : internal pudendal, branch of the anterior internal Iliac artery
Veins : internal pudendal
Nerves : pudendal nerve & the pelvic plexus.

45
Q

Where are the bulbourethral glands ?

A

Located in the urogenital diaphram , posterolateral to the membranous urethra & superior to the bulb of the penis.

46
Q

What is the function of the bulbourethral glands?

A

Secrete mucous / alkaline material to neutralise acid and in sexual arousal.

47
Q

Which part of the male urethra is least distensible?

A

The membranous part.

Surrounded by the external urinary sphincter and also some ligaments in this region.

48
Q

Which part of the urethra is the most likely to be effected by BPH ?

A

Prostatic urethra

49
Q

What is the embryological derivation of the urethra?

A

The urogenital sinus (endoderm).

50
Q

Describe the anatomical location of the prostate gland ?

A
Base : neck of bladder 
Apex : urethral sphincter and deep perineal muscles 
Posterior : ampulla of rectum 
Inferiolateral : levator ani
Anteriorly : urethral sphincter
51
Q

What are the three zones of the prostate gland and comment on their embryological origins?

A

Transitional zone - this surrounds the urethra and is located centrally. Urogenital sinus
Peripheral zone - the main bulk of the gland, what is palpable in a DRE. Urogenital sinus.
Central zone - this surrounds the ejaculatory ducts & is a derivative of the paramesonephric ducts.

52
Q

Where are you most likely to be effected by BPH?

A

Transitional zone or middle lobule

Present early with symptoms of urinary incontinence.

53
Q

Where are you most likely to suffer from prostatic cancer ?

A

Peripheral zone

54
Q

Where can prostate cancer spread through?

A

Lymphatics - the sacral and internal iliac nodes
Venous - Boston plexuses posterior to the bladder which is continous with the internal vertebral plexus. It can therefore travel to the brain and the vertebrae.

55
Q

What secretion is released from the prostate gland ?

A

PSA , acid phosphatase.

Factors to prevent clotting of the semen. Therefore secrete proteolytic enzymes.

56
Q

What is the role of the sympathetic innervation of the prostate?

A

The SMC of the prostate is innervated by the autonomic fibres, this will contract the gland to cause release of the glandular contents when there is ejaculation (shoot- > sympathetic, point -> parasympathetic)

57
Q

Which four male internal genetila are embryologically derived from the mesonephric ducts?

A
Seminal vesicles 
Epididymis 
Ejaculatory duct 
vas Deferens 
(SEED)
58
Q

Where are the seminal vesicles located?

A

Located between bladder fundus and the rectum (rectovesicle pouch)

59
Q

What epithelium is in the seminal vesicles and what is it influenced by?

A

Pseudostratified columnar in a honeycombed lobulated appearance, it is lined by mucosa.
Responds to testosterone which will increase the amount of secretions and will make the cells taller (hypertrophy)

60
Q

What is the n/v/l of the seminal glands ?

A

Vasculature- branches of the internal iliac artery
Lymphatics - external and internal iliac
Innervation - sympathetic (shoot)

61
Q

What are the contents of the seminal vesicle secretions?

A

Pg- to minimise female immune response to semen
Clotting factors - to prevent fluid losing fluidity in female repro tract
Fructose - energy source
Alkaline fluid - to minimise/neutralise the acidity of the male urethra and female repro tract

62
Q

When can the seminal glands be felt & why is this useful ?

A

When the bladder is at full capacity the glands are palpable and can be massaged to release fluid which can be diagnostically tested (for STI)
DRE - digital rectal examination

63
Q

What problems can occur in the seminal glands ?

A

Seminal gland abscess (post infection)
If ruptured the pus can spread into the peritoneal cavity.
(Swollen glands are palpable in DRE)

64
Q

Where are the bulbourethral glands found & what is their embroylogical origin ?

A

The pea shaped exocrine glands (tubuloalveolar) are found enclosed in the fibres of the external urethral sphincter and are found posterolateral to the membranous urethra & superior to the bulb of the penis.
The ducts of the gland penetrate the perineal membrane (urogenital diaphragm) to enter into the proximal part of the spongey urethra.
They are a derivative of the urogenital sinus .

65
Q

What is the n/v/l of the bulbourethral glands ?

A

Vasculature - arteries to the build of the penis
Lymphatics - internal and external iliac nodes
Innervation - prostatic plexus (sympathetic -> shoot)