session 4

Question 1

what is central precocious puberty

Answer 1

precocious puberty with elevated GnRH levels

Question 2

causes central precocious puberty

Answer 2

idiopathic, CNS lesions, pituitary tumours

Question 3

pathophysiology of central precocious puberty

Answer 3

premature activation of HPA axis, early initiation of puberty, early development of secondary sexual characteristics

Question 4

how to diagnose central precocious puberty

Answer 4

lab tests show
- increased basal LH and FSH
GnRH stimulation test shows
- LH and FSH increase after GnRH delivered

Question 5

what is peripheral precocious puberty

Answer 5

precocious puberty without elevated GnRH levels

Question 6

cause peripheral precocious puberty

Answer 6

increased androgen production, CAH, leydig cell tumout, increased oestrogen production

Question 7

lab tests for peripheral precocious puberty

Answer 7

increased oestrogen or testosterone, decreased LH or FSH

Question 8

receptor and product FSH

Answer 8

granulosa cell, oestrogen

Question 9

receptor and product LH

Answer 9

theca cell, androgens

Question 10

when should earliest sign of puberty in boys be observed

Answer 10

14 years

Question 11

when should earliest sign of puberty in girls be seen

Answer 11

13 years

Question 12

what hormone stimulates endometrial proliferation, and at what stage in the cycle does it occur

Answer 12

oestrogen, proliferative phase

Question 13

in midfollicular phase, what is responsible for supression of FSH release

Answer 13

rising inhibin levels

Question 14

where does LH act

Answer 14

leidig cells to produce testosterone

Question 15

where does FSH act

Answer 15

sertoli cells to stimulate spermatogenesis

Question 16

what causes variation in menstrual cycle

Answer 16

the follicular cycle