Session 1

Question 1

Where does HCO3 reabsorption take place?

Answer 1

early PCT

Question 2

What is the dominant anion in the early PCT?

Answer 2

HCO3

Question 3

Dominant anion in late PCT?

Answer 3

Cl

Question 4

What controls ECF osmolarity?

Answer 4

ADH

Question 5

What controls ECF volume?

Answer 5

RAAS

Question 6

Name arteries supplying the ureter?

Answer 6

Internal iliac, common iliac, uterine/testicular

Question 7

Name pumps involved in HCO3 reabsorption?

Answer 7

NHE apical pumps H out to join HC03 and Na inwards to be reabsorbed via Na/K pump, and AE exchanges HCO3 out for Cl in

Question 8

Name glucose transporters and the side they belong

Answer 8

apical SGLT2 is 3Na in one glucose in, basolateral GLUT2 is just glucose out

Question 9

Which apical transporters involve sodium?

Answer 9

Phosphate (2Na in, 1 Pi in)
Glucose (SGLT2 3 Na in, 1 glucose in)
Amino acids (3Na in, 1 aa in)
Calcium (TRPV6 1Ca in 1Mg in)
Urea (3Na in 1 urea in) 
Hydrogen out (NHE 1Na in, 1H out)

Question 10

Which 3 things require receptor mediated endocytosis for PCT transport?

Answer 10

Vitamin D3
Vitamin B12
Albumin

Question 11

Which receptor mediates endocytosis for vitamins D3 and B12 in the PCT?

Answer 11

Megalin receptor

Question 12

What is B12 carried by?

Answer 12

Transcoalbumin

Question 13

Name Na transporters in each stage of the nephron

Answer 13

PCT- NHE
TAL- NKCC
DCT- NCCT, ENaC
CD- ENaC

Question 14

What is NKCC?

Answer 14

1Na 1K 2Cl- co-transporter

Question 15

What is NCCT?

Answer 15

Sodium chloride co-transporter

Question 16

Describe normal size and position of kidney

Answer 16

11cong, 6cm wife, 3cm thick

T11/12 to l3/4