Serum Screening In Pregnancy Flashcards
What level of AFP is considered abnormal?
Greater than 2.0 to 2.5 MOM (multiples of the median)
When is the triple or quadruple screen done in pregnancy?
Between 15-21 weeks ( in 2nd trimester)
- can’t be done later than that or is in accurate
What is the first step after an abnormal triple test (AFP levels) ?
Get an ultrasound
What do you want to look for in the ultrasound after a negative screen?
Looking for estimation of gestational age and for twinning. Also need to rule out fetal demise
- MCC of abnormal is wrong dating, can also be due to multiple babies
What are the two things used in the first semester screening for downs? What are the levels in abnormal screens? What third finding on US can be seen
- PAPP-A –> decreased
- Free B-hCG –> decreased
3 nuchal translucency is thickened
60% of Downs cases are detected with the triple screen results as what? (3 things)
1: hCG –> elevated
2: msAFP-> low
3: unconjugated estradiol–> low
Pregnancies with elevated msAFP that. Have no identified cause are at risk for what 4 birth issues?
- Stillbirth
- Growth restriction
- Preeclampsia
- Placental abruption
