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OBGYN > Serum Screening in Pregnancy > Flashcards

Serum Screening in Pregnancy Flashcards

1
Q

effect on msAFP? underestimation of GA

A

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2
Q

effect on msAFP? multiple gestations

A

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3
Q

effect on msAFP? neural tube defects

A

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4
Q

effect on msAFP? abd wall defects

A

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5
Q

effect on msAFP? cystic hygroma

A

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6
Q

effect on msAFP? fetal skin defects

A

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7
Q

effect on msAFP? sacrococcygeal teratoma

A

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8
Q

effect on msAFP? decreased maternal weight

A

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9
Q

effect on msAFP? oligohydramnios

A

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10
Q

effect on msAFP? overestimation of GA

A

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11
Q

effect on msAFP? chromosomal trisomies

A

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12
Q

effect on msAFP? molar pregnancy

A

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13
Q

effect on msAFP? fetal death

A

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14
Q

effect on msAFP? increased maternal weight

A

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15
Q

1st trimester screening results? When? Trisomy 21

A

1st trimester - between 10-13wks

  1. PAPP-A: down
  2. b-hCG: up
  3. nuchal translucency: thick
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16
Q

2nd trimester screening results? When? Trisomy 21

A

2nd trimester - between 15-21wks

  1. uEstriol - down
  2. AFP - down
  3. hCG - up
  4. (inhibin A) - up
17
Q

1st trimester screening results? When? Trisomy 18

A

1st trimester - between 10-13 wks

  1. PAPP-A: down
  2. b-hCG: down
  3. nuchal translucency

18 - every test is down

18
Q

2nd trimester screening results? When? Trisomy 18

A

2nd trimester - between 15-21 wks

  1. uEstriol - down
  2. AFP - down
  3. hCG - down
  4. (inhibin A) - down

18 - every test is down

19
Q

1st trimester screening results? When? Trisomy 13

A

1st trimester - between 10-13 wks

  1. PAPP-A - down
  2. b-hCG - down
  3. nuchal translucency
20
Q

2nd trimester screening results? When? Trisomy 13

A

not available

21
Q

teratogen? masculinization of females (labial fusion)

A

androgens

22
Q

teratogen? fetal alcohol syndrome, IUGR, microcephaly

A

alcohol

23
Q

teratogen? fetal hydantoin syndrome, IUGR, microcephaly, facial defects

A

phenytoin (dilantin)

24
Q

teratogen? heart and great vessel defects (Epstein)

A

Li

25
Q

teratogen? skeletal defects, limb defects

A

methotrexate

26
Q

teratogen? facial defects, neural tube defects

A

retinoic acid

27
Q

teratogen? skull anomalies, limb defects, miscarriage, renal tubule dysgenesis, renal failure in neonate, oligohydramnios

A

ACE inhibitors

28
Q

teratogen? CNS and skeletal defects

A

warfarin

29
Q

teratogen? neural tube defects

A

valproic acid, carbamazepine, retinoic acid

30
Q

Condition? size>date 2/2 hydramnios, double bubble

A

Down syndrome w/ duodenal atresion

31
Q

elevated msAFP w/o identifying etiology -> prognosis?

A

increased risk of stillbirth, IUGR, preeclampsia and placental abruption -> closely monitor

OBGYN (20 decks)

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