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PoD 1 > Serum Complement > Flashcards

Serum Complement Flashcards

1
Q

Enzymatic activity

A 
C1r
C1s
C2a
Bb
D
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2
Q

Inflammatory activity

A

C4a
C3a
C5a

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3
Q

MAC

A 
C5b
C6
C7
C8
C9
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4
Q

Classic pathway

A 
1 
4
2
3
5-9 
MAC
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5
Q

Lectin

A

4
2
3

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6
Q

Alternative

A

3 (spontaneous , slow, small amnts)
B
D

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7
Q

MAC formation

A 
After C3
C4b2a
Amplification 
C4b2a3b 
5-9 
MAC
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8
Q

Pathways converge at

A

C3

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9
Q

Activation of classic pathway

A

IgM ***

IgG1,3

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10
Q

Protein binding activity

A

C1q
C4b
C3b

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11
Q

Anaphylatoxins

A

C5a>C3a>C4a

Stimulate cellular de granulation
Chemo tactic for neutrophils

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12
Q

C1

A

Binds directly to pathogen or to Ab (indirect)

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13
Q

C3 convertase

CP

A

C4b2a

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14
Q

C5 convertase

CP

A

C4b2a3b

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15
Q

Endogenous complement inhibitors

A

DAF
MCP
C1 inhibitor

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PoD 1 (2 decks)

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