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PoD 1 > Antibiotics > Flashcards

Antibiotics Flashcards

1
Q

Rifampin

A

Transcription

Initiation

Binds subunit of RNAP

No formation of first phosphodiester bond
Used for mycobacteria and G+

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2
Q

Streptolydigin

A

Transcription

Elongation

Beta subunit of RNAP

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3
Q

Actinomycin D

Too toxic for clinical use

A

Transcription

Elongation

dsDNA

Blocks movement of the holoenzyme
Can inhibit DNA replication at higher concentration

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4
Q

Streptomycin

And other aminoglycosides: gentamycin, neomycin, amikacin

A

Translation

Initiation

Blocks assembly of 70s initiation complex
Causes misreading by ribosomes that have passed through initiation

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5
Q

Tetracycline

Doxycycline
Minocycline

A

Translation

Elongation

Blocks binding of charged tRNAs to the acceptor site

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6
Q

Chloramphenicol

A

Translation

Elongation

Binds on peptidyltransferase

Blocks the transpeptidation step

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7
Q

Erythromycin

A

Translation

Elongation

Blocks translocation

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8
Q

Quinolones

A

Dna replication

Blocks negative supercoiling
Blocks replication and cell growth

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PoD 1 (2 decks)

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