Sertraline

Question 1

Sertraline
Brand Name

Answer 1

Zoloft

Question 2

Sertraline
Formulations

Answer 2

Capsule: 150mg, 200mg
Concentrate: 20mg/mL
Tablet: 25mg, 50mg, 100mg

Question 3

Sertraline
On-Label Indications

Answer 3

MDD
OCD
PMDD

Question 4

Sertraline
Off-Label Indications

Answer 4

GAD

Question 5

Sertraline
MOA

Answer 5

SSRI
Presynaptic serotonin (5HT) reuptake inhibitor

Question 6

Sertraline
CYP450 Pathway

Answer 6

CYP3A4 substrate
CYP2D6 - weak inhibitor

Question 7

Sertraline
Dose Range (Adult)

Answer 7

50mg-200mg QD

Question 8

Sertraline
Titration

Answer 8

Increase by 25mg/week

Question 9

Sertraline
Dosing: Kidney Impairement

Answer 9

No adjustment needed

Question 10

Sertraline
Dosing: Liver Impairment

Answer 10

Mild impairment (class A): 50% dose reduction
Moderate-severe (B or C): use not recommended

Question 11

Sertraline
Dosing: Elderly

Answer 11

Start 25mg QD

Question 12

Sertraline
Pregnancy/Breastfeeding

Answer 12

Maternal benefit must outweigh fetal/newborn risk

Question 13

Sertraline
Side Effects

Answer 13

Sexual dysfunction
Insomnia
GI upset

Question 14

Sertraline
Contraindications

Answer 14

Hypersensitivity
MAOI
Alcohol intolerance/Disulfiram use (oral solution contains alcohol)

Question 15

Sertraline
Major Interactions

Answer 15

MAOIs
Disulfiram
Pimozide

Question 16

Sertraline
Common Interactions

Answer 16

NSAIDs
SNRIs
St. John’s Wort

Question 17

Sertraline
Required Monitoring

Answer 17

Mood changes: suicidality/psychosis
Serotonin syndrome

Question 18

Sertraline
Pearls

Answer 18

TBD