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SSRIs > Fluoxetine > Flashcards

Fluoxetine Flashcards

1
Q

Fluoxetine
Brand Name

A

Prozac

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2
Q

Fluoxetine
Formulations

A

Capsule: 10mg, 20mg, 40mg
Delayed-release capsule: 90mg

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3
Q

Fluoxetine
On-label indications

A

MDD
OCD
Bulimia

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4
Q

Fluoxetine
Off-label indications

A

GAD
Social Anxiety Disorder
Fibromyalgia

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5
Q

Fluoxetine
MOA

A

SSRI
Serotonin (5HT2C) antagonist

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6
Q

Fluoxetine
CYP450 Pathway

A

CYP2D6 - STRONG inhibitor
CYP2C19 - moderate inhibitor

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7
Q

Fluoxetine
Dose Range

A

20mg-80mg QD
Delayed-release: 90mg QD

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8
Q

Fluoxetine
Titration

A

Increase by 20mg Qweek

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9
Q

Fluoxetine
Dosing: Kidney Impairment

A

No adjustment needed

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10
Q

Fluoxetine
Dosing: Liver Impairment

A

up to 50% reduction

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11
Q

Fluoxetine
Dosing: Elderly

A

Start 10mg-60mg QD
Increase by 10-20mg Q2-3weeks

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12
Q

Fluoxetine
Tapering

A

Slowly over 1-4 weeks

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13
Q

Fluoxetine
Side Effects

A

Sexual dysfunction
GI upset
Anxiety

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14
Q

Fluoxetine
Contraindications

A

MAOI
-5 week washout period before starting MAOI
Linezolid
Thioridazine

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15
Q

Fluoxetine
Interactions (major)

A

Note: least likely SSRI to have drug interactions
MAOI
Pimozide
Thioridazine

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16
Q

Fluoxetine
Interactions (common)

A

Common:
Antivirals
CNS Depressants
CYP2D6 Inhibitors

17
Q

Fluoxetine
Required Monitoring

A

Mood changes - suicidality and mania
Serotonin syndrome
Neuroleptic malignant syndrome

18
Q

Fluoxetine
Pearls

A

Least likely SSRI to have drug interactions
5 week washout before starting MAOI

SSRIs (2 decks)

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