Serology Rationale 1 Flashcards
Discovery of the T cell receptor gene:
a. 1978
b. 1880
c. 1901
d. 1984
d. 1984
All of the following are correct match, except:
a. Ellie Metchnikoff: Phagocytosis
b. Koehler, Millstein: Monoclonal antibodies
c. Snell, Dausset, Benaceraf: MHC
d. Thomas, Murray: RIA
d. Thomas, Murray: RIA
Rosalyn Yalow: RIA
In searching for a cure for TB, Koch was first to observe which phenomenon?
a. Bacterial agglutination
b. Precipitation
c. Phagocytosis
d. Delayed hypersensitivity
d. Delayed hypersensitivity
Chronic granulomatous disease represents a defect of:
a. Oxidative metabolism
b. Abnormal granulation of neutrophils
c. Diapedesis
d. Chemotaxis
a. Oxidative metabolism
A primary function of the eosinophil is:
a. Phagocytosis
b. Reacting in acute, systemic hypersensitivity reactions
c. Suppression of the inflammatory response
d. Antigen recognition
c. Suppression of the inflammatory response
Protein(s) that are released by eosinophils and are toxic to helminthes is(are):
a. Major basic protein
b. Eosinophil cationic protein
c. Perforin
d. Both A and B
d. Both A and B
Major basic protein and Eosinophil cationic protein
Of the circulating lymphocytes in peripheral blood, which are in the greatest percentages?
a. NK cells
b. Null lymphocytes
c. B lymphocytes
d. T lymphocytes
d. T lymphocytes
Large granular lymphocytes (LGL) is synonymous with:
a. B cell
b. T helper cell
c. T cytotoxic cell
d. NK cells
d. NK cells
The major role of NK cells is lysis of virally infected cells. Which one of the following molecules is released by activated NK cells and causes destruction of the infected cell? a, Major basic protein b. Superoxide c. Perforin d. Lysozyme
c. Perforin
The major role of neutrophils is phagocytosis. Which one of the following events is not associated with some aspect of neutrophil function?
a. Recognition of antigen via primitive pattern receptor patterns
b. Recognition of opsonins on bacteria
c. Secretion of perforin
d. Activation of the NADPH oxidase
c. Secretion of perforin
A cut on person’s fingers becomes contaminated with the bacterium Staphylococcus aureus. The first response by the immune system consists of the activity of:
a. B cells
b. Monocytes
c. Neutrophils
d. T cells
c. Neutrophils
Monocytes and macrophages plays a role in the mononuclear phagocytic system. For an antibody-coated antigen to be phagocytised, what part of the antibody molecule fits into a receptor on the phagocytic cell?
a. Fc region
b. Fab region
c. Hinge region
d. Variable region
a. Fc region
A function of the cell mediated immune response not associated with humoral immunity is:
a. Defense against viral and bacterial infection
b. Defense against fungal and bacterial infection
c. Initiation of rejection of foreign tissues and tumors
d. Antibody production
c. Initiation of rejection of foreign tissues and tumors
The major role of cytotoxic T cells and NK cells is to destroy:
a. Extracellular bacteria
b. Intracellular bacteria
c. Virally infected cell
d. Helminthes
c. Virally infected cells
Which on of the following cells recognizes a cell surface complex consisting of antigenic peptide complexed with MHC protein?
a. Phagocytes
b. Eosinophils
c. T cells
d. B cells
c. T cells
An individual recovering from a bacterial infection and tests positive for antibodies to a protein normally found in the cytoplasm of this bacterium. Which of the following statements is true of this situation?
a. Class I molecules have presented bacterial antigen to CD8+ T cells
b. Class I molecules have presented bacterial antigen to CD4+ T cells
c. Class II molecules have presented bacterial antigen to CD4+ T cells
d. B cells have recognized bacterial antigen without help from T cells
c. Class II molecules have presented bacterial antigen to CD4+ T cells
A living donor is being sought for a child who requires kidney transplant. The best odds of finding an MHC compatible donor occur between the child and:
a. Sibling (brother or sister)
b. An unrelated individual
c. The child’s father
d. The child’s mother
a. Sibling (brother or sister) - 50% chance
The following phenotypes resulted from blood typing a mother, 6-month-old baby and alleged father in a case of paternity testing.
ABO>Rh>HLA
Mother; A; ce; A2,A29,B12,B17
Baby; O; ce; A2,A3,B12,B15
Alleged father; A; DCce; A3,A9,B5,B7
Which of the following statements is true? The alleged father:
a. Is excluded by the ABO system
b. Is excluded by the Rh system
c. Is excluded by the HLA system
d. Cannot be ruled out
c. Is excluded by the HLA system
Which of the following is a potent mediator in acute-phase response?
a. IL-1
b. IL-2
c. IL-3
d. IL-4
a. IL-1
Which of the following enhances the cytolytic activity of lymphokine-activated killer cells (LAK)?
a. IL-1
b. IL-2
c. IL-3
d. IL-4
b. IL-2
Which of the following are target cells for IL-3? a, Myeloid precursors b. Lymphoid precursors c. Erythroid precursors d. AOTA
d. AOTA
Myeloid precursors, Lymphoid precursors, Erythroid precursors
Flow cytometry results on a patient reveal a lack of cells with CD2 and CD3. What does this indicate?
a. Lack of B cells
b. Lack of T cells
c. Lack of Monocytes
d. Lack of NK cells
b. Lack of T cells
Which cell surface marker is termed the common acute lymphoblastic leukemia marker?
a. CD19
b. CD10
c. CD23
d. CD21
b. CD10
Which of the following activates both T and B cells?
a. PHA
b. Con A
c. LPS
d. PWM
d. PWM
Pokeweed mitogen
