Serology 2 Flashcards

1
Q

What are the 3 ways that immunoglobulins and antibodies are measured?

A
  1. Quantitative& Qualitative
  2. Agglutinin Titers
  3. Antibody Titers
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2
Q

__________ is a screening test to semiquantitatively measure various proteins which are electrically separated.

A

Electrophoresis

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3
Q

___ and ____- lymphocytes are derived from bone marrow stem cells?

A

B and T- lymphocytes

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4
Q

_____ precursors migrate to the thymus.

A

T-Cell

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5
Q

_____ maturation occurs in the bone marrow and lymphoid tissue

A

B-Cell

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6
Q

T- cell = ________ immunity?

A

Cellular (cell-mediated)

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7
Q

B-cell= __________ immunity?

A

Humoral

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8
Q

During Cell mediated immunity (T-cell) macrophages become activated and interact with ___________?

A

T- Lymphocytes

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9
Q

This immunity is an inflammatory process that begins after non=specific detection and processing of infectious agents by macrophages

A

Cell-mediated

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10
Q

Phagocytosis and killing of infectious agents ensue during ______ immunity?

A

cell-mediated

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11
Q

Humoral immunity is:
A. T-Cell
B. B-Cell

A

B-Cell

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12
Q

With humoral immunity you can expect to see a rise in which Ig first then which other Ig?

A

IgM first then IgG

*maggy goes before ginny

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13
Q

What is the universal blood donor type?

A

O negative

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14
Q

________ are substances capable of binding to an antibody.

A

Antigen

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15
Q

________ is from the patients serum (produced by lymphocytes)

A

ANtibody

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16
Q

If the antigen (test) and the antobody (serum) form a reaction, ________ or ________ will occur.

A

agglutination or clumping

17
Q

would a decrease in titer result in a patient feeling better or worse?

18
Q

1:256 ratio shows the second number representing the ________ of the organism

A

virulence (high is more virulent)

19
Q

The STD syphillis is caused by the _________ __________ pallidium.

A

spirochete treponema

20
Q

The primary stage of syphillis begins __-___ weeks after infection is recognized by a chancre.

21
Q

With primary syphillis is the chancre painful?

A

no Painless

22
Q

Which stage of syphillis goes systematic resulting in fever, malise, RASH, and may have CNS involvement.

A

secondary syphillis

23
Q

The teritary stage is ___-___ years post infection and are soft granulomatous lesions called _______.

A

3-10 years

Gummas

24
Q

Teritary syphillis may be asymptomatic or have CNS involvement known as (_________) leading to insanity

A

Neurosyphillis

25
What type of joints are associated with teritary syphillis?
Charcot's joints
26
Nontreponemal (screening) test may be _______ in the teritary stage.
NEgative
27
What is the exam of choice for finding T. Pallidum?
Darkfield exam (genital lesions)
28
Is nontreponemal tests used in patients suspected of syphillis a screening or confirmatory test?
Screening
29
T/F: Treponemal tests are confirmatory tests
True
30
Nontreponemal tests include ________, ________. These test measure _______ and _____ antibodu and are NOT specific to T. Pallium.
VDRL, RPR | IgM and IgG
31
____________ tests are used to confirm reactive nontreponemal tests as they are more sensitive.
Treponemal
32
What is the MC etiology of charcot joints?
Diabetes, also common with teritary stage syphillis
33
What is another name for charcot joints
Hypertrophic neurotrophic
34
What is the name of the spirochete associated with lyme disease?
Barrelia burgdorferi
35
what is the hallmark sign for lyme disease?
bulls eye rash | red macule at site of bite with erythema migrans
36
What are 4 common early symptoms with lyme disease?
fever, HA, Fatigue, depression
37
Can lyme disease influence the joints, heart and CNS?
Yes all are later symptoms if left untreated
38
Lyme disease testing is recommended by the CDC; what two-tiered protocol is used?
ELISA (first) then a Western Blot is run
39
non-specific with False positives common various AI diseases such as: (RA, Lupus, Mono, AIDS and ______)
nephritis