Sepsis Definitions Flashcards
What is Colonisation?
The presence of microbes in the body WITHOUT inflammation
What is Infection?
Inflammation that is caused by the invasion of a microbe e.g. in abscess or bacteraemia
What is Bacteraemia?
The presence of viable bacteria in the blood
What is Sepsis?
Life-threatening organ dysfunction caused by the dysregulated host response (overreaction) to an infection
What is Septic Shock?
Subset of sepsis defined by circulatory and cellular/metabolic dysfunction which has a higher rate of mortality as the patient does not do well, despite adequate fluid resuscitation
What are the 3 Main Signs of Sepsis?
Persistent Hypotension
Vasopressors needed to keep MAP >65mmHg
Lactate Levels >2mmol/L
How do the 3 Septic Signs differ slightly in Septic Shock?
Persistent Hypotension remains despite adequate fluid resuscitation
MAP remains <65mmHg despite first line vasopressor therapy; Noradrenaline
What is SIRS?
Systemic Inflammatory Response Syndrome
Criteria that is used for indicating inflammation
What is the SIRS Criteria?
Temperature <36 or >38
Pulse >90bpm
Respiratory Rate >20 or PaCO2 <32mmHg
WBC Count <4000 or >12000 or 10% Immature Neutrophils
How is Sepsis indicated by SIRS Criteria?
SIRS Score >2 and Confirmed Infection present
What is qSOFA?
Quick Systemic Organ Function Assessment
Prognostic Criteria used to indicate outcome rather than diagnosis
What is the qSOFA Criteria?
Respiratory Rate is 22 or More
Systolic Blood Pressure is 100mmHg or Less
Altered Glasgow Coma Scale (GCS) <14
What are the Associated Mortality Rates with the qSOFA Criteria?
qSOFA Score of 0 = Mortality Rate of <1%
qSOFA Score of 1 = Mortality Rate of 2-3%
qSOFA Score of 2 or more = Mortality Rate of 10% or more
What NEWS indicates Sepsis?
NEWS of 5 or more with the presence of infection from patient history
NEWS >5 indicates hourly monitoring
NEWS >7 indicates continuous monitoring
