SEPSIS Flashcards
3 main features of sepsis syndrome
- Microbial invasion of sterile sites
- Systemic inflammatory response
- Organ damage
Specific feature of meningococcal sepsis
Rash that doesnt fade under pressure, i.e. capillary bleeding
Evidence markers of systemic inflammatory response
2+ of:
- Temp >38 or <36
- HR> 90/min
- RR> 20/min
- WBC > 12x106/ml or <4x106
SIRS criteria are not specific for infection organ dysfunction
Define Bacteraemia
- Presence of micro-organisms in bloodstream
- May be transiet e.g. dental procedures
- May be terminated by host immune system
Define septicaemia
A syndrome consisting of:
- Sepsis
- Bacteraemia
Sepsis damage brought about by cytokine cascade in seps

Non-infectious causes of SIRS
Trauma
Burns
Pancreatitis
Haemorrhage; particularly intra-cranial
COMMUNITy ONSET SEPSIS: UTI/pyelonephritis
E. coli
COMMUNIT ONSET SEPSIS: Pneumonia
S. pneumoniae
COMMUNITY ONSET SEPSIS: Skin/soft tissue/joint/bone
S.aureus
S. pyogenes
COMMUNITY ONSET SEPSIS: Meningitis
N. meningitidis
COMMUNITY ONSET SEPSIS: Intra-abdominal infection
E.coli
COMMUNITY ONSET SEPSIS: Infective endocarditis
Streptococci
S. aures
Risk factors for infective endocarditis
Valvular disease
Prostethic valve
Intravenous drug use
Central lines
Implantable cardiac devices
Common organisms infective endocarditits
Streptococci (inc enterococci)
S. aureus
HACEK
PVE, also coagulase negatice staph
Clinical considerations for S. pyogenes
- Common cause of tonsillitis and scarlet ever
- Penicillin sensitive
- Antistreptolysin O antibodies rise after tonsilitis
Rheumatic fever and S.pyogenes relation
- Rheumatic fever may be caused by cross-reactivity following S.pyogenes infection
- Damage to connective tissue
- Fever, polyarthritis, carditis
- Untreated repeated attacks can cause valve damage
Presentation in infective endocardits

Diagnosing infective enocarditis

Signs of Infective endocarditis

Management of infective ednocarditis

How many sets of microbiology results before ABs in sepsis
Minimum 2 in ideal circumstences
NUH Sepsis Red Flags

The sepsis sic resuscitation bundle
