Sepsis

Question 1

antibiotic choice for neutropenic sepsis

Answer 1

piperacillin with tazobactam (tazocin)

Question 1

what does a new LBBB suggest

Answer 1

new left bundle branch block is always pathological and never normal
usually a sign of STEMI

Question 2

what does beta, alpha and gamma haemolysis show

Answer 2

beta = clear=> complete haemolysis
alpha = green=> partial haemolysis
gamma => no haemolysis

Question 3

usual source of streptococcus alpha-haemolytic organism

Answer 3

strep viridans = GI tract

Question 4

definition of septic shock

Answer 4

sepsis AND both of:
persistent hypotension
lactate > 2mmol/L
despite adequate interventions

Question 5

best test to diagnoses C.diff

Answer 5

stool toxin test

Question 6

what is the associated mortality in E.Coli infection

Answer 6

haemolytic uraemic syndrome
- AKI
haemolytic anaemia
thrombocytopenia

Question 7

what antibiotic has no activity against anaerobes

Answer 7

gentamicin

Question 8

what antibiotic is active against gram positive organisms only

Answer 8

vancomycin

Question 9

what antibiotic is active against gram negative organisms only

Answer 9

gentamicin

Question 10

4c antibiotics

Answer 10

co-amoxiclav
cephalosporins - e.g. ceftriaxone
fluroquinolones - e.g. ciprofloxacin
clindamycin

Question 11

what drugs are safe in penicillin allergy

Answer 11

tetracyclines - e.g. doxycycline
quinolones- e.g. ciprofloxacin
macrolides- e.g. clarithromycin
aminoglycosides - e.g. gentamicin

Question 12

best antibiotic cover for penicillin allergy staph aureus infection

Answer 12

IV vancomycin

Question 13

what is the empirical cover antibiotics

Answer 13

amoxicillin- gram positive
gentamicin - gram negative
metronidazole - anaerobes

Question 14

best treatment of choice for MRSA blood stream infection

Answer 14

IV vancomycin

Question 15

H.Pylori management

Answer 15

amoxicillin
clarithromycin
PPI

Question 16

antibiotic choice for uncomplicated female Lower UTI

Answer 16

3 days nitrofuratoin or trimethorpim PO

Question 17

antibiotic choice for uncatheterised male UTI

Answer 17

nitrofuratoin or trimethoprim

Question 18

antibiotic choice for complicated UTI or pyelonephritis in primary care

Answer 18

co-amoxiclav ( co-trimoxazole if penicillin allergic) 7 days

Question 19

antibiotic for complicated UTI or pyelonephritis in hospital

Answer 19

amoxicillin and gentamicin IV for 3 days
(co-trimoxazole and gentamicin if penicillin allergy)

Question 20

management of c.diff infection

Answer 20

oral vancomycin