sepsis

Question 2

what happens to respiration in sepsis

Answer 2

anaerobic respiration = lactate produced

Question 3

Early response of innate immune system

Answer 3

IL1/6/8/12/18, TNF-alpha, IFN-y

Activation of complement, coagulation, phagocytes

Question 4

Compensatory response in sepsis

Answer 4

Tachypnea, altered level of consciousness, hypotension

Question 5

how will you know coagulation is becoming dysregulated in sepsis

Answer 5

Thrombocytopenia, increased INR or aPTT, disseminated intravascular coagulation, petechiae

Question 6

why are platelets low

Answer 6

they are being used in capillaries and not big veins where blood is taken from

Question 7

2016 Septic shock definition

Answer 7

infection induced hypotension not responding to fluid administration and requiring vasopressors

requires elevated lactate

Question 8

SIRS criteria (not super useful)

Answer 8

temp > 38 degrees or <36
HR >90
RR >20 or PaCO2 <32mmHg
WBC >12,000/mm3, or <4,000/mm3

Question 9

Q SOFA

Answer 9

see pic

Question 10

venous pressure

Answer 10

5-20

Question 11

is arterio venous system continuous

Answer 11

no

Question 12

bp measure pressure of

Answer 12

arteries

Question 13

higher CVP means

Answer 13

higher risk of dying of sepsis

Question 14

what are some drugs that raise lactate

Answer 14

metformin and beta agonists

Question 15

how much of 1L of fluid would remain in intravascular compartment

Answer 15

1/5 within half an hour

Question 16

Vasopressors 1-6 hours after onset for sepsis

Answer 16

Norepinephrine, epinephrine, vasopressin

Question 17

Which fluids in sepsis

Answer 17

Colloids, crystalloid

Question 18

other good things in treating sepsis

Answer 18

Enteral feeding, insulin therapy, lung protective ventilation, urinary catheter