Sepsis

Question 1

Bacteraemia vs sepsis

Answer 1

bacteraemia is presence of bacteria in blood whereas sepsis is dysregulated host response to infection that leads to life-threatening organ dysfunction

Question 2

Septic shock definition

Answer 2

Sepsis and BOTH of:
-persistent hypotension requiring vasopressors to maintain MAP =/>65mmHg AND,
-lactate greater than or equal to 2mmol/l
DESPITE adequate volume resus

Question 3

Which 4 types of infections commonly lead to sepsis in order

Answer 3

lung infection,
UTI,
gut,
skin

Question 4

Symptoms & signs (8)

Answer 4

shivering, 
fever,
extreme pain,
clammy/sweaty, 
confusion,
SOB, 
High heart rate, 
feel like they're dying

Question 5

Sepsis 6 - BUFALO

Answer 5

Blood cultures + septic screen, U&Es, 
Urine output hourly, 
Fluid resus, 
Antibiotics IV, 
Lactate measurement, 
Oxygen

Question 6

Sepsis 6 should be delivered within?

Answer 6

1 hour

Question 7

Lyme disease bug

Answer 7

borrelia burgdorferi

Question 8

Syphilis bug

Answer 8

treponema pallidum

Question 9

what does shigella usually cause

Answer 9

travellers diarrhoea

Question 10

Diagnosing sepsis

Answer 10

NEWS >5 + signs of infection

Question 11

List 4 types of microbiological investigations to consider in infection

Answer 11

Cultures (blood, stool, urine, wound, tissue), 
Microscopy (stool, urine, CSF, sputum), 
serology, 
antigen detection, 
PCR

Question 12

What viruses relevant to sepsis (4)

Answer 12

Covid,
influenza,
herpes simplex in brain,
HIV

Question 13

What fungi relevant to sepsis (2)

Answer 13

Candida,

aspergillus