Sepsis Flashcards
normal HCT female
36-44
normal HCT male
41-50
normal WBC level
5-10K
normal plt level
150-400K
normal albumin
3.4-5.4
normal protein level
6-8.3
normal BUN
6-20
normal Cr level
0.6-1.3
normal Na level
135-145
normal K level
3.5-5.3
normal bilirubin level
0.1-1.2
normal procalcitonin level
<0.1
normal lactate level
<1
normal PT
11-12.5
normal CRP
<12
normal CPK female
26-192
normal CPK male
39-308
what does a Cr above 2 indicate
acute/chronic renal failure
normal hgb
8-12
normal HCT level
35-505
what is SIRS
exaggerated defense response
SIRS criteria classes X4
2+ of the following:
temp
HR
RR
WBC count
SIRS temp criteria
> 100.5 or <96.8
SIRS HR criteria
> 90 bpm
SIRS RR criteria
> 20 bpm or PaCO2 <32
SIRS WBC count criteria
> 12K or <4K or 10% immature bands
Sepsis criteria
SIRS + confirmed or suspected infection
Severe sepsis criteria
sepsis +
signs of end organ damage +
hypotension +
lactate >4
septic shock criteria
severe sepsis with persistent:
signs of end organ damage
hypotesion
lactate >4
3 key responses of body to sepsis
activation of inflammation
activation of coagulation
decreased fibrinolysis
sepsis s/s X6
2 SIRS
AMS
hyperglycemia
hypoxemia
oliguria
hypotension
normal urine output rate
30 mL/hr
0.5 mL/kg/hr
1 hour bundle for sepsis
measure lactate level
obtain blood cultures BEFORE administering antibiotics
administer broad-spectrum antibiotics
fluid bolus
vasopressors to keep MAP >65
how much should be bolused in a septic bundle
30 mL/kg
when does fluid resuscitation stop in septic bundle
CVP is 8-12
what is used in a septic bundle fluid resuscitation
crystalloid
what is CVP
central venous pressure monitoring
what does CVP measure
direct measurement of BP in right atrium and vena cava
normal CVP
2-6
ideal CVP in septic shock
8-12
what can elevate CVP X5
fluid overload
right HF
Pleural effusion
cardiac tamponade
mechanical ventilation
what can decrease CVP X3
hypovolemia
hypovolemic shock
negative pressure breathing
pulmonary MODS s/s X5
tachypnea
dyspnea
shallow breathing
hypoxemia
crackles if edema
pulmonary MODS labs X2
ABG
CVP
pulmonary MODS ABG results X3
low PaCO2
<80 PaO2
low Pao2/FiO2 ratio
pulmonary MODS CVP result
> 8
CV Dysfunction MODS s/s X4
tachycardia
hypotension
decreased capillary refill
skin mottling
Renal dysfunction MODS s/s X6
elevated Cr
decreased U/O
Electrolyte imbalance (Na)
fluid retention
N/V
Fatigue
Hepatic dysfunction MODS s/s X7
jaundice
confusion
edema
AST/ALT
low albumin
increased bilirubin
increased CPK
Neuro dysfunction MODS s/s X5
confusion/delirium
agitation
lethargy
change in LOC
seizures
endocrine dysfunction MODS major s/s
decreased wound healing
hyperglycemic endocrine issues MODS X5
polydipsia
polyuria
irritability
stomach pain
dry mouth
hypoglycemic endocrine issues MODS X3
lethargy
pallor
hunger
endocrine dysfunction MODS labs X4
glucose/CMP
AST/ALT
albumin
serum amylase and ligase
what does amylase and ligase show
pancreatitis - blood sugar issues in non DM
GI dysfunction MODS s/s X5
abd pain
abd distention
hypoactive/absent bowel sounds
tarry stool
bright red stool
what does a tarry stool indicate
upper GI issue
what does a bright red stool indicate
lower GI issue
anti-inflammatory foods X5
Garlic
cinnamon
fish
lean meat
DASH/Mediterranean diet
early septic shock findings X4
fever
tachycardia
tachypnea
WIDENED pulse pressure
progressive shock findings X3
decreased LOC
respiratory depression
decreased CVP
how is fluid resuscitation evaluated
VS
cap refill
skin temp
urine output
CVP
passive leg raises by HCP
early sepsis skin temp
warm/flushed
late sepsis skin temp
cool/clammy
what do passive leg raises do
transfer blood from legs and abdominal compartments to the brain
first pressor used
levophed
what does levophed do
cause vasoconstriction
what does vasopressin do
holds onto water and increases volume
what is the second pressor used
vasopressin
how does dopamine vary by dose
constricts in high doses
dilates in low doses
when should abx be started in sepsis
within first hour
initial DIC symptoms x7
excessive clotting
thrombosis
gangrene
altered LOC/CVA
SOB/PE
bowel ischemia/infarction
acute renal failure
late signs of DIC X6
excessive bleeding
petechiae
hematuria
oozing from IV sites
GI bleeding
oozing gums
fibrinogen in DIC
decreased
PT in DIC
increases
plt count in DIC
decreased
fibrin products in DIC
increased
d-dimer in DIC
increased
normal d-dimer
<0.5