Sepsis Flashcards
The primary tissue or organ that is targeted in sepsis is
endothelium (Cells that line the blood vessels).
Sepsis is defined as life-threatening organ dysfunction caused by a _ response to infection.
dysregulated host
The increased respiratory rate in sepsis is due to
increased hydrogen ion concentration
Hypotension in hyperdynamic sepsis is due to …
a. loss of intravascular volume and impaired cardiac contractility
b. impaired vascular tone and loss of intravascular volume
Source control in cases of suspected bacterial sepsis always includes all of the following except…
surgery
RED ZONE CRITERIA: BP, LACTATE, BASE
SBP <90 MMHG
LACTATE >4MM/OL
BASE EXCESS <5.0
YELLOW ZONE; RR, SP02, SBP, HR, LOC, TEMP
<10 >25 RR Sp02 <95% SBP <100 mmhg HR <50 > 120 LOC Temp <35.5 or >38.5 Lactate >2 mm/ol
Fluid resus ; ED and Ward protocol
Emergency Department Give initial 20mL/kg bolus STAT, if no response repeat 20mL/kg STAT
Inpatient Initial 250-500mL bolus STAT, if no response repeat 250-500mL STAT
Fluid resus aim
Use crystalloid e.g saline
Systolic above >100 mmHg
Sepsis 6
- Hudson’s mask
- Blood cultures
- Blood e.g. lactate
- antibiotics
- fluids resus
- monitor
Priorities after blood e.g. lactate
Antibiotics and Fluid resus
antibiotic for neutropenic
> 30 minutes
septic shock or meningococcal
> 1 hour
other spesis
> 2 hours