Sepsi And Septic Shock

Question 1

Sepsis
-Hippocrates: wrote that sepsis was characterised by rotting flesh and festering wounds

Galen: sepsis a laudable event required for wound healing

GERM theory:
Was proposed by semmelweis, pasture 9th century sepsis
-blood poisoning

Answer 1

• they defined sepsis as a systemic inflammatory response to infection
• septic shock: subset of sepsis cases that were complicated by hypotension despite adequate fluid resuscitation along with perfusion abnormalities

Question 2

Definition of sepsis base on dysregulated host response to infection that leads to acute organ dysfunction

Answer 2

Septic shock: defined a subset of sepsis cases in which underlying circulatory and cellualar/metabolic abnormalities are profound enough to substantially increase mortality risk.

Sepsis:

(1) suspected infection
(2) acute organ dysfuction, defined as a increase by two or more points from baseline (if known) on the sequential ( or sepsis-relate) organ failure assessment (SOFA) score

Criteria; septic shock include sepsis plus the need for vasopresor therapy
>65mmHg with serum lactate concentration >2.0 mol/L despite adequate fluid resuscitation

Question 3

Etiology of sepsis:

1) . Pneumonia is the most common source accounting for about half of cases
2. Intraabdominal
3. Genitourinary infection

Answer 3

Blood culture are typically positive isolates

1. Staphylococcus aureus and streptococcus pneumoniae are the most common gram positive aeroginosa are the most common gram
2. Escherichia coli, Kleibsiella species, pseudomonas aeroginosa are most common gram-negative isolates

Question 4

Epidemiology:

Sepsis and septic shock depend on how acute organ

Answer 4

Pathogenesis

-SIRS: sepsis were considere the result of an excessive inflammatory host response (SIRS)