Semester 1 Flashcards
1
Q
Monogenic hypertension (2)
A
Kidney : Liddle’s syndrome
Steroid metabolism : CYPIIB2 mutation
2
Q
Development of essential HT (4)
A
- Genetic inheritance
- Disorder of neuroendocrine metabolism
- Salt sensitivity
- Vascular aging
3
Q
Disorders of neuroendocrine system that cause HT (5)
A
- RAAS
- Natriuretic peptide
- Endothelium
- SNS hyperactivation
- Immune system
4
Q
Neurohormonal response to HT (3)
A
- Hemodynamic reaction
- Inflammatory response
- Hypertrophic response
5
Q
Prevalence of obesity in HU
A
5% of adults are overweight and of those, 27.6% are obese
6
Q
3 adipocytokines
A
- adiponectin
- leptin
- resistin
7
Q
Symptoms of diabetes (3)
A
- polyuria
- polydipsia
- weight loss
8
Q
Stages of T1D
A
- asymptomatic
- dysglycemia
- symptomatic
9
Q
T2D genetic variant
A
TCFL2
10
Q
Cells targeted by hyperglycemia
A
Cells that cannot regulate ic glc
- endothelial cells
- schwann cells
- mesangial cells
11
Q
Prothrombic state (3)
A
- TF increase
- Thrombomodulin decrease
- Heparin decrease
12
Q
Part of kidney affected by diabetic retinopathy
A
inner retinal layers, perfused by central retinal artery
13
Q
What drugs in T2D CVD risk
A
- statin to decrease cholesterol synthesis
- aspirin for platelet control
14
Q
Congenital hypothyroidism
A
- primary : iodine defficiency
- secondary : panhypopituitarism (no hormones)
- thyroid hormone resistance
15
Q
Horomone levels in acquired hypothyroidsm
A
- primary : T3/T4 low, TSH high, goitre
- central : T3,T4,TSH low, no goitre
