Selective alpha2 agonists

Question 1

Methyldopa

Answer 1

Selective alpha2 agonist
It is an antihypertensive medication
Primarily used to treat hypertension
Used in gestational hypertension
SIDE EFFECTS: dry mouth, sedation, bradycardia, constipation, transient hypertension, relapsing hypertension

Question 2

Clonidine

Answer 2

Antihypertensive drug
Selective alpha2 agonist
It has central hypotensive effects
It acts on alpha2 adrenergic receptors in the brain —> decreases sympathetic outflow from the CNS, leading to reduced heart rate and blood vessel dilation, which helps lower blood pressure
USE: hypertensive crisis
SIDE EFFECTS: dry mouth, sedation, bradycardia, constipation, transient hypertension, relapsing hypertension

Question 3

Rilmenidine

Answer 3

Antihypertensive drug
Selective alpha2 agonist
Its less sedating than older ones
SIDE EFFECTS: dry mouth, sedation, bradycardia, constipation, transient hypertension, relapsing hypertension

Question 4

Tizanidine

Answer 4

Inhibition by stimulation of presynaptic alpha2 receptors–> muscle relaxant
Centrally targeted striated muscle relaxant
Uses: reduction of muscle spasticity (short acting)

Question 5

Dexmedetomidine

Answer 5

Selective alpha2 agonist
General anesthesia