Seizuring patient - SA/LA Flashcards

1
Q

Define seizure

A

electrical imbalance between excitation and inhibition, they have a certain rhythmicity

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2
Q

How can seizures be classified by CS?

A

FOCAL: when people appear absent
GENERALISED: tonic, clonic,
* don’t use the petit-mal and grand-mal seizure

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3
Q

Describe focal seizures

A

SIMPLE FOCAL: no loss of consciousness
COMPLEX FOCAL: impairment of consciousness
FOCAL SEIZURE WITH SECONDARY GENERALISATION

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4
Q

2 types of generalised seizures

A

Convulsive or non-convulsive

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5
Q

Define status epilepticus

A
  • prolonged seizure activity
  • > / 5 mins (clinical)
  • > / 30 mins (basic science) –> brain damage
  • life-threatening emergency always
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6
Q

Describe cluster seizures

A

> / 2 seizures in a 24 hour period, very serious!

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7
Q

Name 4 classifications of seizures

A
  • prodrome
  • aura
  • ictus
  • post-ictal
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8
Q

Define prodrome

A

behaviour changes that occur hours or days before the seizure

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9
Q

Define aura

A

sensory/ focal onset seizures may start with a sensory experience such as a perceived smell or a feeling of deja vu. The existence of aura in animals is difficult to prove but owners often report a behavior change of their dog minutes before the ictus.

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10
Q

What is ictus?

A

the seizure event itsel

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11
Q

What is post-ictus?

A

neurological status alternations hours or days after the seizure

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12
Q

How can seizures be classified over time?

A
  • self-limiting
  • clustered or continuous (status epilepticus)
  • reflexive
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13
Q

Describe a self-limiting seizure

A

= focal or generalised types

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14
Q

Describe a clustered or continuous (status epilepticus) seizure

A

= focal or generalised types

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15
Q

What causes a reflexive seizure?

A

a precipitating stimuli

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16
Q

Classic - CS - feline seizure

A
  • lip smacking
  • hypersalivation
  • yowling (consider feline dementia as alternative ddx in older cats with this CS).
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17
Q

Name 5 events that can mimic seizures.

A
  • syncope
  • narcolepsy
  • pain
  • vestibular syndrome
  • movement disorders (e.g. Scotty Cramp)
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18
Q

Outline syncope

A
  • partial or complete loss of consciousnesss
  • lack of motor activity
  • no post-ictal signs
  • shorter in duration
  • can mimic seizures
19
Q

What is narcolepsy?

A

= sleeping disorder, very rare

  • stimulated often by excited, food, drugs
  • can mimic seizures
20
Q

Outline different breeds and movement disorders

A
  • scotty cramp
  • CKCS - episodes of tetany, hypertonicity, deer-stalking
  • Norwich terriers
  • Boxers - paroxysmal dystonic choreathetosis
  • Bichon frises - similar to boxers
21
Q

Classic signs of seizures

A
  • typically last 1 minute
  • exhibit several stages
  • often, but not always, occur at rest or out of sleep
  • clonic movemetns (rhythmic mm contractions are common in both partial and generalised seizures)
  • most recurrent seizures respond at least in part to AEDs
22
Q

What is an EEG?

A

= electroencephalogram, easures the electrical activity of the brain

23
Q

T/F: a seizure can happen without pathology

24
Q

How can seizures be classified by aetiology?

A
  • SYMPTOMATIC or SECONDARY: structural brain lesion
  • REACTIVE SEIZURE: metabolic or toxic cause
  • IDIOPATHIC or PRIMARY EPILEPSY: suspected genetic cause
  • POSSIBLE SYMPTOMATIC or CRYPTOGENIC SEIZURE: rule out only via PME
25
What is a cryptogenic seizure?
one of obscure or uncertain origin
26
How can seizures be classified by location?
INTRA-CRANIAL: functional (idiopathic epilepsy) or structural (symptomatic epilepsy, possible symptomatic epilepsy) EXTRA-CRANIAL: Intrinsic (metabolic - reactive seizure) or extrinsic (toxic - reactive seizures)
27
3 categories of extracranial epilepsy
- electrolyte imbalances - energy deprivation - organ dysfunction
28
Give examples of electrolyte imbalances causing extracranial epilepsy
hypernatraemia, hyponatraemia, hypocalcaemia
29
2 examples of energy deprivation extra-cranial seizures
thiamine deficiency and hypoglycaemia
30
2 examples of organ dysfunction extracranial epilepsy
- uraemic encephalopathy | - HE
31
Outline species and idiopathic epilepsy
DOG: 6 months to 6 years CAT GENERALISED SEIZURES: various breeds, e.g GSD PARTIAL SEIZURES with/without 2nd generalisation: springer spaniels
32
Outline epilepsy in horses (signalment)
- Arab foals - congenital, grow out of it - Foal with PAS (neonatal maladjustment syndrome) - Adults (due to structural or metabolic brain disease, migrating parasite, previous trauma etc, intracarotid injection!)
33
Ddx (ordered) - seizures in animals
- Metabolic (PSS, hypoglycaemia) - Infectious diseases - Congenital - (toxic, trauma)
34
Ddx (ordered) - seizures in animals 6 months - 6 years
- Idiopathic epilepsy - Inflammatory/ infectious - Metabolic - (neoplasia, toxic, trauma)
35
Ddx (ordered) - seizures in animals > 6 years
- Neoplasia - Idiopathic epilepsy (late-onset) - Inflammatory/ infectious - (metabolic) - (toxic, trauma)
36
Describe disease progression of metabolic seizures
waxing and waning
37
Ddx - inter-ictal exam findings, normal
- Idiopathic epilepsy - metabolic (wax and wane phenomenon) - Neoplasia (silent area of brain, early in disease) - (toxic)
38
Ddx - inter-ictal exam findings, abnormal, symmetrical
- Metabolic - Toxic - Hydrocephalus - Degenerative - (midline structural disease)
39
Ddx - inter-ictal exam findings, abnormal, Asymmetrical
- Neoplasia - Inflammatory/ infectious - anomalies
40
Ddx = lateralising seizures, symmetrical, generalised onset
- idiopathic epilepsy - metabolic - toxic - degenerative - hydrocephalus - trauma - midline structural problems (pituitary tumour)
41
Ddx = lateralising seizures, Asymmetrical, FOCAL onset
- inflammatory/ infectious - neoplasia - anomalies - trauma - cryptogenic and idiopathic
42
What is the minimum database for extracranial causes of seizures?
- CBC and cytology - Biochem - Ammonia (if indicated) - resting bile acids (in small animals, dynamic bile acid test) - UA (uncommon in horses) - BP in mature small animals (especially cats - cardiac work up) - Further diagnostics depending on signalment/ hx and PE
43
Diagnostics - intracranial causes of seizures
- Imaging - brain - MRI and CT - CLINICAL PATHOLOGY: - CSF (wbc, differential cell count, protein content) - POSITIVE brain imaging or inflammatory CSF for infectious agents