Seizures for Pharm

Question 1

Primary goal of seizure meds

Answer 1

selective effect on hyperexcitable neurons

Question 2

Anti-seizure meds mechanism: front line drug

Answer 2

decrease sodium entry into firing neurons

Question 3

Anti-seizure meds mechanism: last front line drug

Answer 3

decrease calcium into thalamic neurons

Question 4

Anti-seizure meds mechanism: barbituates/bzd

Answer 4

increase GABA inhibition effect

Question 5

Anti-seizure meds mechanism: 2nd gen drug

Answer 5

decrease release/effect of excitatory amino acids

Question 6

Seizure meds minor side effects

Answer 6

dizziness, sedation, HA, in-coordination, GI problems

Question 7

Seizure meds severe side effects

Answer 7

liver toxicity
increase risk of birth defect
aplastic anemia/agranulocytosis

Question 8

Seizure withdrawn sucessfully 60-70% depends on:

Answer 8

early childhood onset of seizures
normal neuro exam before withdrawal
control of seizures for 1st year
seizure free for 2 years while on meds