Seizure ADE

Question 1

Carbatrol

Answer 1

Diplopia, blurred vision, nystagmus, ataxia, dizziness, HA, N/V, hypotnatremia, RS: SJS, agranulocytosis

Question 2

Onfi

Answer 2

Somnolence, fever, lethargy, URTI RS: SJS, resp. depression, thrombocytopenia

Question 3

Zaronitin

Answer 3

N/V RS: SJS, SLE, Agranulocytosis

Question 4

Potiga

Answer 4

Dizziness, somnolence, memory impairment, diplopia RS: Ocular effects/ vision loss, BMS, nephrolithiasis

Question 5

Felbatol

Answer 5

Anorexia, insomnia, wt loss, NV. RS: Aplastic anemia, acute liver failure

Question 6

Cerebyx

Answer 6

Nystagmus, dizziness, pruritus, HA, somnolence, fever, paresthesias RS: CNS depression, cardiovascular collapse, bradycardia, hypotension

Question 7

Neurontin

Answer 7

Fatigue, somnolence, dizziness, and ataxia, wt gain, edema, behavioral changes (kids)

Question 8

Vimpat

Answer 8

Dizziness, N/V, diplopia, nystagmus, ataxia, abnormal coordination

Question 9

Lamictal

Answer 9

Diplopia, drowsiness, ataxia, HA, nausea RS: rash, SJS/TEN, hypersensitivity, rxns, DIC, arthritis

Question 10

Keppra

Answer 10

Mood/behavioral, sedation, fatigue, coordination, difficulties.

Question 11

Trileptal

Answer 11

dizziness, N/V/D, HA, nervousness, dyspepsia RS: hyponatremia, rash

Question 12

Luminal

Answer 12

Drowsiness, fatigue, sedation, depression, cognitive impairment RS: Porphyria, rash, SJS, delayed intellectual development in children

Question 13

Dilantin

Answer 13

Lethargy, fatigue, blurry vision, incoordinaiton, cortical dysfunction, drowsiness, fever, gingival hyperplasia, vit D deficiency, osteomalacia, peripheral neuropathy.

Question 14

Lyrica

Answer 14

Edema, dizziness, somnolence, weight gain, blurred vision, ataxia

Question 15

Mysoline

Answer 15

Diplopia, nystagmus, impotence, anorexia, N/V, drowsiness, ataxia, emotional disturbances RS: Agranulocytosis, morbilliform, skin eruptions, megaloblastic anemia

Question 16

Banzel

Answer 16

HA, dizziness, fatigue, somnolence, nausea, QT shortening RS: Multi-organ hypersensitivity, may increase convulsions and precipitiate SE

Question 17

Gabitril

Answer 17

Dizziness, asthenia, nervousness, tremor, diarrhea, depression RS: increase incidence of nonconvulsive SE in chronic refractory partial epilepsy

Question 18

Topamax

Answer 18

Ataxia, impaired concentration, memory difficulties, confusion, fatigue, somnolence, word finding difficulty RS: Nephrolithiasis, open angle glaucoma, hypohidrosis (kids)

Question 19

Depakote

Answer 19

NV, anorexia, weight gain, alopecia. RS: hepatotoxicity, hyperammonemia, thrombocytopenia, pancreatitis

Question 20

Sabril

Answer 20

Wt gain, edema, neuropathy, fatigue, somnolence RS: may aggravate absence and myoclonic seizures, may reduce visual acuity.

Question 21

Zonegran

Answer 21

Irritability, wt loss, photosensitivity, RS: Sulfa allergy, rash, renal calculi, hypohidrosis

Question 22

These Drugs require Renal Dosing

Answer 22

Clobazam, ezogabine, levetiracetam, pregablin, Primidone, Vigabatrin, zonisamide* (*not recommended crcl <50)

Question 23

These drugs require hepatic dosing

Answer 23

Ezogabine, felbamate, valproic acid (*may contribute to hepatotoxicity, so adjust or d/c?)

Question 24

These drugs require HLA-B* 1502 antigen testing in Asian patients

Answer 24

Carbamazepine, fosphenytoin, Phenytoin, Lamotrigine* and oxcarbazepine* (*according to book, not chart),

Question 25

These drug’s lower the effectiveness of COC’s

Answer 25

Clobazam, felbamate, lamotrigine, runinamide, topirimate, valproic acid* (*COC may decrease VA conc?)

Question 26

These Drugs are Prodrugs

Answer 26

fosphenytoin, Primidone, oxcarbazepine (according to book, not chart).

Question 27

These drugs cause blood dyscrasias

Answer 27

carbamazepine, ethosuxamide, falbamate, fosphenytoin, lamotrigine, oxcatbazepine, phenytoin,