Sedative/Hypnotics Flashcards
BENZODIAZEPINE ANTAGONIST
Flumazenil
TRUE or FALSE
Phenobarbital (long – acting)
Thiopental (ultra – short acting)
TRUE
Classification of
- Clorazepate
- Chlordiazepoxide
Benzodiazepines
Examples of NEWER HYPNOTICS
MOA?
- Eszopiclone
- Zaleplon
- Zolpidem
Work by modulating GABA-A receptors
5-HT1A RECEPTOR AGONIST that has a slow-onset anxiolytic agent
Buspirone
Melatonin vs Orexin
Melatonin -Promotes sleep and regulates the circadian rhythm (body’s internal clock). Binds M1 and M2
Orexin - promotes wakefulness and inhibits REM sleep. Binds to OX1 and OX2
TRUE OR FALSE
Buspirone MOA- Presynaptic 5-HT₁A receptors provide negative feedback to regulate serotonin release.
When stimulated by an agonist, they:
Inhibit the firing of serotonergic neurons.
Reduce serotonin release into the synaptic cleft.
a hypnotic sedative that was introduced by Ciba in 1954 as a safe alternative to barbiturates to treat insomnia. Before long, however, it had become clear that it was just as likely to cause addiction and caused similar withdrawal symptoms
Glutethimide
used to treat anxiety disorders or for short-term relief of the symptoms of anxiety in adults and children 6 years of age and older. It is in a class of medications called tranquilizers.
Meprobamate
