1.0 Pharmacology

Question 1

the study of substances that interact with
living systems through chemical processes,
especially by binding to regulatory
molecules and activating or inhibiting
normal body processes.

Answer 1

Pharmacology

Question 2

Fate of the drug

Answer 2

PHARMACOKINETICS

Question 3

The study of the action and effects of drugs.

Answer 3

Pharmacodynamics

Question 4

The study of the movement of drugs from the
time it is administered into the body until
the time is excreted from the body.

Answer 4

Pharmacokinetics

Question 5

drugs that bind to and activate the receptor which directly or indirectly brings about the effect.

Answer 5

Agonist

Question 6

t binds to a receptor and prevents (blocks or inhibits) a natural compound or a drug to have an effect on the receptor.

Answer 6

Antagonist

Question 7

TRUE OF FALSE
An antagonist has NO activity.
Its intrinsic activity is = 0

Answer 7

TRUE

Question 8

Antagonist binds with the same receptors as
the agonist

Answer 8

Competitive antagonist

Question 9

a pharmacologic antagonist that cannot be
overcome by increasing the dose of agonist.

Answer 9

Non- competitive antagonist

Question 10

TRUE OR FALSE.
Competitive antagonist binds to the same receptor. While, non-competitive binds to another receptor?

Answer 10

TRUE

Question 11

Competitive or Non-competitive antagonist?

Phenoxybenzamine

Answer 11

Non-competitive antagonist

Question 12

A drug that binds to a different receptor, and antagonize action of each other.

Answer 12

Physiologic Antagonism

Question 13

a type of antagonism where a drug counters the effects of another by simple chemical reaction / neutralization

Answer 13

Chemical antagonism

Question 14

A chemical antagonist of heparin?

Answer 14

Protamine sulfate

Question 15

TRUE OR FALSE
Heparin, an anticoagulant, acidic.
Protamine sulfate is a base.

Answer 15

TRUE

Question 16

The range between the minimum toxic dose and the minimum therapeutic dose

Answer 16

Therapeutic window

Question 17

defined as the ratio of the TD50 to the ED50 for some therapeutically relevant effect.

Answer 17

Therapeutic index

Question 18

Drug’s safety margin
* Must be >1 for drug to be useable

Answer 18

Therapeutic index

Question 19

occur if two drugs with the same effect when given together produce an effect that is equal in magnitude to the sum of the effects when the drugs are given individually.

Answer 19

Additive Drug Effects

Question 20

occurs if two drugs with the same effect, when given together, produce an effect that is greater in magnitude than the sum of the effects when the drugs are given individually.

Answer 20

Synergesim

Question 21

Additive or Synergism

Aspirin + Paracetamol

Answer 21

Additive

Question 22

Additive or Synergism

Rexidol [Paracetamol + Caffeine]

Answer 22

Synergesim

Question 23

Additive or Synergism

Penicillin + Aminoglycoside

Answer 23

Synergism

Question 24

Additive or Synergism

Amlodipine + Atenolol

Answer 24

Additive

Question 25

a sulfonamide antibiotic that inhibits dihydropteroate synthase, an enzyme involved in the conversion of para-aminobenzoic acid (PABA) to dihydrofolic acid.

Answer 25

Sulfamethoxazole

Question 26

It inhibits dihydrofolate reductase, preventing the conversion of dihydrofolic acid to tetrahydrofolic acid, which is essential for DNA, RNA, and protein synthesis.

Answer 26

Trimethoprim

Question 27

occurs when a drug's effect is increased by another agent that has no such effect

Answer 27

Potentiation

Question 28

Potentiation or Synergism? Augmentin [Amoxicillin + Clavulanic acid]

Answer 28

Potentiation

Question 29

Ampicillin + Sulbactam

Answer 29

Unasyn

Question 30

Piperacillin + Tazobactam

Answer 30

Zosyn

Question 31

Ticarcillin + Clavulanic Acid

Answer 31

Timentin

Question 32

Amoxicillin + Clavulanic Acid

Answer 32

Amoclav Augmentin Co-Amoxiclav Clavamox