Sedative & Hypnotic Drugs

Question 1

T.t 27. one of the following is a mechanism of action of sedative and hypnotic drug
except
a. GABA a agonist
b. Histamine antagonist
c.Orexin Agonist
d. sympatholytic action

Answer 1

c.Orexin Agonist

Question 2

T.t 28. zaleplone does not cause muscle relaxation because
a. it block BZ1 receptors
b.it block BZ2 receptors
c. it activate BZ1 receptors
d. it does not bind to BZ2 receptors

29. hypnosis is mediated by…. in q28

Answer 2

28 d. it does not bind to BZ2 receptors

29 c. it activate BZ1 receptors

Question 3

T.t 24. one of the following orexin antagonist
a.Suvorexant
b.Spironolactone
c.Celecoxib
d.Tolvaptan

Answer 3

a.Suvorexant

Question 4

T.t 23. all are benzodiazepine: of choice In elderly Except
a.diazepam
b. temazepam
c. lorazepam
d.oxazepam

Answer 4

a.diazepam

Question 5

T.t 25. the hormone of sleep is produced by
a. suprachiasmatic nucleus
b.pineal gland
c.mammillary body
d. posterior hypothalamus

Answer 5

b.pineal gland

Question 6

T.t 21 the following is true regarding BDZ
a.It alters sleep pattern
b. B.All have pharmacologically active
metabolites
c. Induce liver enzyme
d. If taken in higher doses it is less toxic than
other sedatives

Answer 6

d. If taken in higher doses it is less toxic than
other sedatives

Question 7

T.t which important enzyme play role in BDZ metabolizm
a.Cyp 3A4
b. CYp 2e3
c.Cyp 2c9
d. Cyp 2c19

Answer 7

a.Cyp 3A4

Question 8

T.t 19. barbiturate preferred in induction of
general anesthesia is
a. pentobarbital
b.phenobarbital
c.thiopentone
d. phenobarbitone

Answer 8

c.thiopentone

Question 9

T.t 17. all are non BDZ hypnotics except
a. Zolpidem
b.Ziprasidone
c. Zaleplone
d. Zopiclone

18. the shortest acting non BDZ drug among Q17 is……….

Answer 9

17. b.Ziprasidone
18. c. Zaleplone

Question 10

16 . the mechanism of action of barbiturate differ
from that of BDZ in that they
a.do not affect GABA-benzodiazepine chloride channel complex receptor
b. act as inverse agonist at BDZ receptors
c.increse the frequency of chloride channel opening
d.have both GABA facilitatory action as well as GABA mimetic action

Answer 10

d.have both GABA facilitatory action as well as GABA mimetic action

Question 11

T.t 6- Which one of the following statements is correct?
A. Phenobarbital shows analgesic properties.
B. Diazepam and phenobarbital induce the P450 enzyme system.
C. Phenobarbital is useful in the treatment of acute intermittent porphyria.
D.Phenobarbital induces respiratory depression, which is enhanced
by the consumption of ethanol.
E. Buspirone has actions similar to those of the benzodiazepines

Answer 11

D.Phenobarbital induces respiratory depression, which is enhanced
by the consumption of ethanol.

Question 12

T.t 10-Which of the following activity of hepatic hypnotics increase the drug-metabolizing enzyme systems?
A.Phenobarbital.
B. Flurazepam.
C. Zaleplon.
D. Triazolam.

Answer 12

A.Phenobarbital

Question 13

T.t 7 .Which of the following is not related to effects of sedative hypnotic agents
a) Zolpidem is structurally related to
benzodiazepines used in insomnia
b) Triazolam is good benzodiazepine for sleep induction
but poor for maintaining it
c) Barbiturates have multiplicity of sites of action
d) Flumazenil is a BZD analogue which has no intrinsic
activity

Answer 13

a) Zolpidem is structurally related to
benzodiazepines used in insomnia

Question 14

T.t 30. which among treatment of insomnia (Difficult
falling a sleep) does not caue day time sedation
a. Temazepam
b.Flurazepam
c.zaleplone
d. Buspirone

Answer 14

c.zaleplone
d. Buspirone

Question 15

T.t 11- Inverse agonist of benzodiazepine receptor is
a. phenobarbital
b. flumazenil
c. beta carboline
d. Gabapentine

Answer 15

c. beta carboline

Question 16

T.t all of the following CNS stimulant Except
a.Amphetamine
b.cocaine
c. methylphenidate
d. benzodiazepine

Answer 16

d. benzodiazepine

Question 17

T.t 7. - Which of the following benzodiazepine agents
useful in the treatment of patient withspinal cord injury and skeletal muscle spasticity
a)Oxazepam
b) Temazepam
c) Triazolam
d) Diazepam

Answer 17

d) Diazepam

Question 18

T.t 31- which of the following drug that has no effect
on cognitive function on elderly as drug option in
treatment of insomnia
a. Temazepam
b. Zolpidem
c.Remelteon
d.Diphenhydramine

Answer 18

c.Remelteon

Question 19

T.t Which one of the following statements is correct?
A. Benzodiazepines directly open chloride
channels.
B. Benzodiazepines show analgesic actions.
C. Clinical improvement of anxiety requires 2 to 4 weeks
of treatment with benzodiazepines.
D.All benzodiazepines have some sedative effects.
E. Benzodiazepines, like other CNS depressants, readily
produce general anesthesia.

Answer 19

D.All benzodiazepines have some sedative effects.