sedative hyp drugs

Question 1

drugs indicated for m relaxation

Answer 1

diazepam and meptobamate

*NOT the new drugs

Question 2

benzo favored as a hypnotic rather thena sedative and why

Answer 2

triazolam bc short elim half life (2-3 hrs)

Question 3

which drug increases total sleep time

Answer 3

eszopiclone

Question 4

SEs: dizziness, somnolence, fatigue, endo changes (decrease T and increases prolactin

Answer 4

ramelton

Question 5

drugs used for better sleep onset

Answer 5

zalepon, zolpidem, ramelton

Question 6

drugs ehh for sleep probs and yay for sleep probs:

Answer 6

ehh:

• secobarbital, pentobarbital, chloral hydrate
• benzos bc cause daytime dedation

yay:

• zaleplon and zolpidem if trouble going to sleep
• eszopiclone if wake early and not back

Question 7

best and worst benzos for hepatic dis

Answer 7

best: lorazepam and oxazepam (<20h 1/2 life)
worst: diazepam and chlordiazepoxide (>100h 1/2 life)

Question 8

good drugs for anesthesia and why

Answer 8

thiopental and methohexital bc are very lipid soluable and penetrate brain rapidly after IV admin

Question 9

which drug causes daytime anxiety when it is used to tx sleep disorders?

Answer 9

triazolam bc short 1/2 life of 4 hours

Question 10

short term relief of anxiety: promotes sleep in anxious ans tense pt

Answer 10

meprobamate

Question 11

ramelteon MOA

Answer 11

agonist M1 and M2 on suprachiasmic nuclei

Question 12

drugs indicated for seizure management

Answer 12

clonazapam, nitrazepam, lorazepam, diazepam; phenobarbital

*NOT the new drugs

Question 13

which drugs induce CYP450?

Answer 13

phenobarbital and meptobamate

Question 14

for generalized anxiety disorder

Answer 14

buspirone

Question 15

which benzos if hepatic insufficiency and why

Answer 15

oxazepam and lorazepam bc less cumulative toxcity bc less hepatic biotransformation compared to diazepam

Question 16

benzos used for IV anesthesia in combo w other drugs

Answer 16

diazepan, lorazepam, midazolam

Question 17

whick drugs tx withdrawl from physiologic dependence of alch or other sedative-hypnotocs

Answer 17

chlordiazepoxide and diazepam

Question 18

which drugs ahve less withdrawl symp?

Answer 18

zolpidem, zaleplon, eszopiclone (less so than benzos at least)

Question 19

which drug class for acute anxiety attacks?

Answer 19

benzos

Question 20

use w caution in hepatic impairment

Answer 20

ramelton, buspirone,

Question 21

SE’s: tachy, palpitations, nervousness, GI issues, paresthesias, dose-dependent papillaty constriction

Answer 21

buspirone

Question 22

which drugs induce hepatic CYPs

Answer 22

phenobarbital and meprobamate