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drugs of abuse Flashcards

1
Q

molec target of PCP, ketamine

A

NMDAR

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2
Q

ectasy long term use effects:

A

cognitive impairment

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3
Q

effect opoids

A

euphoria

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4
Q

long term effects LSD

A

flashbacks of altered perception yrs after consumption

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5
Q

withdrawal symp: n/v, m aches, lacrimation, rhinorrhea, mydriasis, piloerection, sweating, drh, yawning, fever

A

opioid withdrawal

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6
Q

efects: euphoria, relaxation, feelings of well-being, grandiosity, altered perception of passage of time, withdrawn, bloodshot eyes

A

cannabinoids

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7
Q

MOA amphetamines

A

-reversing action fo biogenic amine transporers at PM –> increased DA, SE, NE in synapse

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8
Q

effects: eupohria, enhanced sensory perceptions, feelings of social closeness, amnesia before sedation/coma

A

GHB

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9
Q

withdrawal: dysphoria, drowsiness (insomnia), irritability, depression

A

amphetamines

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10
Q

THC analogs used medically

A

dronabinol, nabilone

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11
Q

drugs to end addiction to nicotine

A

nicotine (gum, losenge, inhalers, transdermal applications), bupropion, varenicline

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12
Q

use of dronabinol

A

anorexia and wt loss in AIDS and chemo induced n/v

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13
Q

MOA GHB

A
  • activities GABAb –> hyperpolarizes DA neurons and prevents DA release
  • recreational doses: inhibit GABAb
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14
Q

MOA methadone, buprenophrine

A

long-acting opioids used for substiturino therapy

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15
Q

cociane binds to.. and MOA

A

DAT,=> increases DA conc in nuc accumbens
NET => blocks = activates sympathetics => HBP, tachy, ventricualr arrythmias, pupil dilation
SERT

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16
Q

what are the nonaddictive drugs of abuse?

A 
LSD
mescaline
psilocybin
PCP
ketamine
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17
Q

common opoids used

A

morphine, heroin, coedine, oxycodone, meperidine

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18
Q

effects: loss appetite, hyperactivity, lack sleep, incrased risk intracranial hem, ischemic stroke, MI, seizures

A

cociane

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19
Q

Drugs that activate Gio-coupled receptors

A

opoids, cannabinoids, GHB

20
Q

tx opoid withdrawal

A

naloxone, methadone, buprenophrine

21
Q

effect of opoids, cannabinoids, GHB on DA neurons

A

disinhibition

22
Q

ectasy binds to..

A

SERT > DAT, NET

23
Q

withdrawal symp: mood offset: long depression and agression

A

ectasy

24
Q

long term effects PCP

A

schizophrenia-like psychosis

25
Q

withdrawal: restlessness, irritabilty, mild agiatation, insomnia, n, cramping

A

cannabinoids

26
Q

overdose management inhalants

A

supportive care

27
Q

drugs that mediate theri effects via ionotropic receptors

A

nicotine, benzodiazepines/barbituates, alch, inhalants

28
Q

effect inhalants

A

eupohria

29
Q

drugs that bind to transporters of biogenic amines

A

cocaine, amphetamines, ectasy

30
Q

MOA varenicline

A
  • partial nAchR agonist

- ->prevents nicotine stimulation of mesolimbic DA system assoc w nicotine addiction

31
Q

MOA ectasy

A

-reversing action fo biogenic amine transporers at PM –> increased DA, SE, NE in synapse

32
Q

MOA opoids

A

inhibs GABA –>disinhib DA

33
Q

MOA naloxone

A

opoid antagonist

34
Q

use of nabilone

A

refractory n/v assoc w CA chemo and adjunct to chronic pain managment

35
Q

why we use bupropion

A
  • antidepressant

- end nicotine addiciton

36
Q

effect of LSD, mescaline, psilocybin, PCP, ketamine on DA?

A

none bc nonaddictive

37
Q

SEs: psychedelic, HBP, impaired mem, disorientatino, nystagmus, visual alterations

A

PCP

ketamine

38
Q

molec target LSD, mescaline, psilocybin

A

Gq

39
Q

withdrawal: mild: irritabilty, sleeplessness

A

nicotine withdrawal

40
Q

amphetamnes binds to..

A

DAT, SERT, NET, VMAT

41
Q

cannabinoids MOA

A
  • bind to presynap CB1 receptors and inhib release glutamate/GABA
  • disinhibit DA
42
Q

tx for cocaine overdose

A

supportive: control HR/R (propranolol), seizures (diazepam)

43
Q

overdose: hyperthermia, coma, death

A

cociane

44
Q

nicotine MOA

A

agonist nAchR –> DA release!

45
Q

effects: hyperthermia, dehydration, serotonin synd (mental status change, autonomic hyperactivity, neuromusc abns), seizures

A

ectasy

bsp (4 decks)

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