Section 6: Cell Division And Cellular Organisation Flashcards

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1
Q

What happens during interphase in mitosis?

A

During interphase the cell carries out normal functions, but also prepares to divide. The cell’s DNA is unravelled and replicated, to double its genetic content. The organelles are also replicated so it has spare ones, and its ATP content is increased (ATP provides energy needed for cell division).

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2
Q

What are the two types of cell division?

A

There are two types of cell division - mitosis and meiosis.

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3
Q

What is mitosis?

A

Mitosis is the form of cell division that occurs during the cell cycle. It’s needed for the growth of multicellular organisms and for repairing damaged tissues. Some animals, plants and fungi also use it to reproduce asexually. Mitosis is really one continuous process, but it’s described as a series of division stages - prophase, metaphase, anaphase and telophase.

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4
Q

What is the structure of chromosomes like in mitosis?

A

As mitosis begins, the chromosomes are made of two strands joined in the middle by a centromere. The separate strands are called chromatids. Two strands on the same chromosome are called sister chromatids. There are to strands because each chromosome has already made an identical copy of itself during interphase. When mitosis is over, the chromatids end up as one-strand chromosomes in the new daughter cells.

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5
Q

What happens during prophase in mitosis?

A

During prophase l, the chromosomes condense, getting shorter and fatter. Tiny bundles of protein called centrioles start moving to opposite ends of the cell, forming a network of protein fibres across it called the spindle. The nuclear envelope (the membrane around the nucleus) breaks down and chromosomes lie free in the cytoplasm.

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6
Q

What happens during Metaphase in mitosis?

A

During Metaphase I, the chromosomes (each with two chromatids) line up along the middle of the cell (at the spindle equator) and become attached to the spindle by their centromere. At the metaphase checkpoint, the cell checks that all of the chromosomes are attached to the spindle before mitosis can continue.

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7
Q

What happens during Anaphase in mitosis?

A

During Anaphase I, the centromeres divide, separating each pair of sister chromatids. The spindles contract, pulling chromatids to opposite ends of the cell, centromere first.

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8
Q

What happens during Telophase in mitosis?

A

During Telophase I, the chromatids reach the opposite poles on the spindle. They uncoil and become long and thin again. They’re now called chromosomes again. A nuclear envelope forms around each group of chromosomes, so there are now two nuclei.

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9
Q

What happens during cytokinesis?

A

During cytokinesis, the cytoplasm divides. In animal cells, a cleavage furrow forms to divide the cell membrane. There are now two daughter cells that are genetically identical to the original cell an to each other. Cytokinesis usually begins in Anaphase and ends in Telophase. It’s a separate process to mitosis.

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10
Q

Explain and state what the cell cycle is and the steps it involves.

A

The cell cycle is the process that all body cells in multicellular organisms use to grow ad divide. It starts when a cell has been produced by cell division and ends with the cell dividing to produce two identical cells.
The cell cycle consists of a period of cell growth and DNA replication, called interphase, and a period of cell division, called M phase. M phase involves mitosis and cytokinesis. Interphase is subdivided into three separate growth stages. These are called G1, S and G2
The cell cycle is regulated by checkpoints. Checkpoint occur at key points during the cycle to make sure it’s okay for the process to continue.

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11
Q

What happens at the G1 checkpoint?

A

At the G1 checkpoint, the cell checks that the chemicals needed for replication are present and for any damage to the DNA before entering S-phase.

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12
Q

What happens during the G2 checkpoint?

A

At the G2 checkpoint, the cell checks whether all the DNA has been replicated without any damage. If it has, the cell can enter mitosis.

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13
Q

How do you investigate mitosis?

A
You can stain chromosomes so you can see them under a microscope. This means you can watch what happens to them during mitosis. To do this, you need to stain the specimen, put it on a microscope slide and examine it under a microscope. 
Figure 7(on page 141 of the textbook) shows some plant root tip cells on a ‘squash’ microscope slide, viewed under a light microscope. Squashes like this can be made by treating the very tips of growing roots in hydrochloric acid, then breaking them open and spreading the cells thinly on a microscope slide using a mounted needle. A few drops of stain are then added to the spread out cells before they are physically squashed beneath a coverslip. When you look at the slide under he light microscope, you should be able to see cells at different stages of mitosis.
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14
Q

What is and what happens during sexual reproduction?

A

Gametes are the sperm cells in males and egg cells in females. In sexual reproduction two gametes join together at fertilisation to form a zygote, which divides and develops into a new organism.
Normal body cells have the diploid number (2N) of chromosomes – meaning each cell contains two of each chromosome (a pair), one from the mum and one from the dad. The chromosomes that make up each pair are the same size and have the same genes, although they could have different versions of those genes (called alleles). These pairs of matching chromosomes are called homologous chromosomes.
Gametes have a haploid (n) number of chromosomes – there’s only one copy of each chromosome. At fertilisation, a haploid sperm fuses with a haploid egg, making a cell with the normal diploid number of chromosomes. Half of these chromosomes are from the father (the sperm) and half are from the mother (the egg).The diploid cell produced by fertilisation is called a zygote.

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15
Q

What is meiosis?

A

Meiosis is the type of cell division that happens in the reproductive organs to produce gametes. Meiosis involves a reduction division. Cells that divide by meiosis are diploid to start with, but the cells that are formed from meiosis are haploid – the chromosome number halves. Cells formed by meiosis are all genetically different because each new cell ends up with a different combination of chromosomes.

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16
Q

What happens during interphase in meiosis?

A

The whole of meiosis begins with interphase. During interphase, the cell’s DNA unravels and replicates to produce double-armed chromosomes called sister chromatids.

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17
Q

What is meiosis 1?

A

Meiosis involves two divisions – meiosis 1 and meiosis 2. After interphase, the cells enter meiosis 1. Meiosis 1 is the reduction division (it halves the chromosome number). There are four similar stages to each division in meiosis called prophase, metaphase, anaphase and telophase.

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18
Q

What happens in prophase 1?

A

In prophase one, the chromosomes condense, getting shorter and fatter. Homologous chromosomes pair up – number 1 with number 1, 2 with 2, 3 with 3, etc.

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19
Q

What happens during metaphase 1?

A

During metaphase 1, the homologous pairs line up across the centre of the cell and attach to the spindle fibres by their centromeres.

20
Q

What happens during anaphase 1?

A

During anaphase one, the spindles contract, pulling the pairs apart (one chromosome goes each end of the cell).

21
Q

What happens during telophase 1?

A

During telophase 1, a nuclear envelope forms around each group of chromosomes. Cytokinesis (division of the cytoplasm) occurs and two haploid daughter cells are produced.

22
Q

What is meiosis 2?

A

The second division is meiosis 2.
At this stage, the two daughter cells undergo prophase 2, metaphase 2, anaphase 2, Telophase 2 (and cytokinesis) – these are pretty much the same as the stages in meiosis one, except with half the number of chromosomes. In anaphase 2, the sister chromatids are separated – each new daughter cell inherits one chromatid from each chromosome. 4 haploid daughter cells are produced.

23
Q

What is a genetic variation?

A

Genetic variation is the differences that exist between individuals’ genetic material. The reason meiosis is important is that it creates genetic variation – it makes gametes are all genetically different. Then during fertilisation, any egg can fuse with any sperm, which also creates variation. This means new individuals have a new mixture of alleles, making them genetically unique.

24
Q

What are the two main events during meiosis that can lead to genetic variation?

A

Crossing over of chromatids and independent assortment of chromosomes.

25
Q

How can the crossing over of chromatids lead to genetic variation?

A

During prophase 1 of meiosis 1, homologous pairs of chromosomes come together and pair up. The chromatids twist around each other and bits of chromatids swap over. The chromatids still contain the same genes but now have a different combination of alleles. The crossing over of chromatids in meiosis 1 means that each of the four daughter cells formed from meiosis 2 contain chromatids with different alleles.
The chromosomes of homologous pairs come together, chromatids cross over in prophase 1, 1 chromosome from each homologous pair ends up in each cell, each cell has a different chromatid and therefore different set of alleles which increases genetic variation in potential offspring.

26
Q

How does the independent assortment of chromosomes lead to genetic variation?

A

Remember that each homologous pair of chromosomes in your cells is made up of one chromosome from your mum (maternal) and one chromosome from your dad (paternal). When the homologous pairs lineup in metaphase 1 and are separated in anaphase 1, it’s completely random which chromosome from each pair ends up in which daughter cell, so the 4 daughter cells produced by meiosis have completely different combinations of those maternal and paternal chromosomes. This is called independent assortment (separation) of the chromosomes. This ‘shuffling’ of chromosomes leads to the genetic variation in any potential offspring.

27
Q

What are stem cells?

A

Multicellular organisms are made up of many different cell types that are specialised for their function, e.g. liver cells, muscle cells and white blood cells. All these specialised cell types originally came from stem cells. Stem cells are unspecialised cells – they can develop into different types of cell. All multicellular organisms have some form of stem cell.
In animals, adult stem cells are used to replace damaged cells.
Plants are always growing, so stem cells are needed to make new shoots and roots throughout their lives. Stem cells in plants can differentiate into various plant tissues.

28
Q

Give an example of stem cells in humans.

A

In humans, stem cells are found in early embryos and a few places in adults. In the first few days of an embryos life, any of its cells can develop into any type of human cell – they’re all stem cells. In adults, stem cells are found in a few places (e.g. bone marrow), but they’re not as flexible – they can only develop into a limited range of cells.

29
Q

What is cell differentiation?

A

Stem cells divide to become new cells, which then become specialised. The process by which a cell becomes specialised for its job is called differentiation. Stem cells are also able to divide to produce more undifferentiated stem cells, i.e. they can renew themselves.

30
Q

Give an example of cell differentiation in humans.

A

Bones are living organisms, containing nerves and blood vessels. The main bones of the body have marrow in the centres. Here, adults stem cells divide and differentiate to replace worn out blood cells, – erythrocytes (red blood cells) and neutrophils (white blood cells that help to fight infection).

31
Q

Give an example of stem cells found in plants.

A

In plants, stem cells are found in meristems (part of the plant where growth can take place). In the root and the stem, stem cells of the vascular cambium divide and differentiate to become xylem vessels and phloem sieve tubes.

32
Q

When are stem cells used in medicine and give examples.

A

Stem cells can develop into different specialised cell types, so they have a huge potential for use in medicine. Scientists think they could be used to repair damaged tissues (like the heart) and treat neurological disorders (like Alzheimer’s and Parkinson’s).
Stem cells are also used by scientists researching developmental biology, i.e. how organisms grow and develop. Studying stem cells can help us to understand more about things like developmental disorders and cancer.
For example, heart disease is a big problem in many countries. If it results in heart tissue becoming damaged, the body is unable to sufficiently replace the damaged cells. Researchers are currently trying to develop ways of using stem cells to make replacement heart cells to repair the damaged tissue. Another example is that with Alzheimer’s, nerve cells in the brain die in increasing numbers. This results in severe memory loss. Researchers are hoping to use stem cells to regrow healthy nerve cells in people with Alzheimer’s. Also patients with Parkinson’s suffer from tremors that they cannot control. The disease causes the loss of a particular type of nerve cells found in the brain. The cells release a chemical called dopamine, which is needed to control movement. Transplanted stem cells may help to regenerate the dopamine-producing cells.

33
Q

What are specialised cells?

A

Once cells differentiate, they have a specific function. The structure is adapted to perform that function.

34
Q

How are erythrocytes specialised cells?

A

erythrocytes (red blood cells) carry oxygen in the blood. The biconcave disk shape provides a large surface area for gas exchange. They have no nucleus so there is more room for haemoglobin, the protein that carries oxygen.

35
Q

How are neutrophils specialised cells?

A

Neutrophils (a type of white blood cell) defend the body against disease. Their flexible shape allows them to engulf foreign particles or pathogens. The many lysosomes in the cytoplasm contains digestive enzymes to breakdown the engulfed particles.

36
Q

How are epithelial cells specialised cells?

A

Epithelial cells cover the surfaces of organs. The cells a joined by interlinking cell membranes and a membrane at their base. Ciliated epithelium (e.g. in the airways) have cilia that beat to move particles away. Other epithelia (e.g. in the small intestine) have microvilli – folds in the cell membrane that increase the cell surface area. Squamous epithelia (e.g. in the lungs) are very thin to allow efficient diffusion of gases.

37
Q

How are sperm cells specialised cells?

A

Sperm cells (male sex cells) have a flagellum (tail) so they can swim to the egg (female sex cell). They also have lots of mitochondria to provide the energy to swim. The acrosome contains digestive enzymes to enable the sperm to penetrate the surface of the egg.

38
Q

How are palisade mesophyll cells specialised cells?

A

Palisade mesophyll cells and leaves do most of the photosynthesis. They contain many chloroplasts, so they can absorb a lot of sunlight. The walls are thin, so carbon dioxide can easily diffuse into the cell.

39
Q

How are root hair cells specialised cells?

A

Root hair cells absorb water and mineral ions from the soil. They have a large surface area for absorption and a thin, permeable cell wall, for the entry of water and ions. The cytoplasm contains extra mitochondria to provide the energy needed for active transport.

40
Q

How are guard cells specialised cells?

A

Guard cells are found in pairs, with a gap between them to form a stoma. This is one of the tiny pores in the surface of the leaf used for gas exchange. In the light, guard cells take up water (into their vacuoles) and become turgid. The thin outer walls and thickened inner walls force them to bend outwards, opening the stomata. This allows the leaves exchange gases for photosynthesis.

41
Q

What are tissues?

A

A tissue is a group of cells (plus any extracellular material secreted by them) that are specialised to work together to carry out a particular function. The tissue can contain more than one cell type.

42
Q

Give four examples of animal tissues.

A

Squamous epithelium tissue is a single layer of flat cells lining a surface. It’s found in many places in the body, including the alveoli in the lungs, and provides a thin exchange surface for substances to diffuse across quickly.
Ciliated epithelium is a layer of cells covered in cilia. It’s found on surfaces where things need to be moved – in the trachea for instance, where the cilia waft mucus along.
Muscle tissue is made up of bundles of elongated cells called muscle fibres. There are three different types of muscle tissue: smooth (e.g. found lining the stomach wall), cardiac (found in the heart) and skeletal (which you use to move). They are all slightly different in structure.
Cartilage is the type of connective-tissue found in the joints. It’s also shapes and supports the ears, nose and windpipe. It’s formed when cells called chondroblasts secrete an extracellular matrix (a jelly like substance containing protein fibres), which they become trapped inside.

43
Q

Give two examples of plant tissues.

A

Xylem tissue is a plant tissue with two jobs – it transports water in the plant, and it supports the plant. It contains hollow xylem vessel cells, which are dead, and living parenchyma cells.
Phloem tissue transports sugars around the plant. It’s the arranged in tubes and is made up of cells, companion cells, and some ordinary plant cells. Each sieve cell has end walls with holes in them, so that sap can move easily through them. These end walls are called sieve plates.

44
Q

What is an organ?

A

An organ is a group of different tissues that work together to perform a particular function.

45
Q

Give two examples of organs.

A

The lungs are an animal organ which carry out gas exchange. They contain squamous epithelium tissue (in the alveoli) and ciliated epithelium tissue (in the bronchi, etc). They also have elastic connective tissue and vascular tissue (in the blood vessels).
The leaf is a plant organ which carries out gas exchange and photosynthesis. It contains palaside tissue, as well as epidermal tissue (to prevent water loss from the lead), and xylem and phloem tissues in the veins.

46
Q

What is an organ system?

A

Organs work together to form organ systems - each system has a particular function.

47
Q

Do you two examples of organ systems.

A

The respiratory system is made up of all the organs, tissues and cells involved in gas exchange. The lungs, trachea, larynx, nose, mouth and diagram are all part of the respiratory system.
The circulatory system is made up of the organs involved in the blood supply. The heart, arteries, veins and capillaries are all parts of the system.