Section 5 Flashcards
The differential diagnosis of a solitary intraparenchymal lesion in an adult p-fossa is what until proven otherwise?
● A. Abscess
● B. Metastasis
● C. Hemangioma
● D. Hemorrhage
● E. Medulloblastoma
B. Metastasis
PHACES syndrome: acronym for a group of findings including which of the following?
● A. Posterior fossa malformations
● B. Truncal hemangioma
● C. Arterial anomalies of the head and neck
● D. Coarctation of the aorta and cardiac defects
● E. Eye anomalies and sternal cleft
B. Truncal hemangioma
Differentiating feature of medulloblastoma and ependymoma are all of the following except?
● A. Ependymoma which tends to grow into the 4th ventricle from the floor
● B. Ependymoma may grow through the foramen of Luschka and/or Magendie
● C. Ependymomas tend to be inhomogeneous on T1WI MRI
● D. The exophytic component of ependymomas tends to be high signal on T2WI MRI
● E. Calcifications are more common in medulloblastoma
E. Calcifications are more common in medulloblastoma
Tumor passing from the posterior fossa to the middle fossa though the incisura is highly suggestive of which of the following?
● A. Vestibular schwannoma
● B. Epidermoid cyst
● C. Cysticercosis
● D. Arachnoid cyst
● E. Lipoma
B. Epidermoid cyst
All of the following are long tract signs found in foramen magnum lesion except?
● A. Brisk muscle stretch reflexes
● B. Loss of abdominal cutaneous reflexes
● C. Neurogenic bladder
● D. Contralateral Horner syndrome
● E. Nystagmus: classically downbeat
D. Contralateral Horner syndrome
Which of following is not included in D/Dx of corpus callosum lesion?
● A. Lymphoma
● B. MS plaque
● C. Lipoma
● D. Diffuse axonal injury from trauma
● E. None of the above
E. None of the above
Following conditions can lead to pituitary pseudotumor formation except?
● A. Primary hyperthyroidism
● B. Primary hypogonadism
● C. Pregnancy
● D. Ectopic GHRH secretion
● E. Intracranial hypotension
A. Primary hyperthyroidism
Differentiating features of juxta sellar meningioma from macroadenoma are all except?
● A. Homogenous contrast enhancement
● B. Dural tail
● C. Suprasellar epicenter
● D. Pushing the carotids laterally
● E. None of the above
D. Pushing the carotids laterally
All of the following are included in metastatic workup of intracranial lesions except?
● A. CT of chest
● B. CT of abdomen
● C. Bone scan
● D. PSA
● E. Mammogram
C. Bone scan
What is the most common malignancy of the skull?
● A. Osteogenic sarcoma
● B. Chondrogenic sarcoma
● C. Hemangiosarcoma
● D. Fibrosarcoma
● E. None of the above
A. Osteogenic sarcoma
Classic X-ray finding of “starburst” appearance is seen in which of the following?
● A. Hemangioblastoma
● B. Metastasis
● C. Multiple myeloma
● D. Lymphoma
● E. Brown tumor of hyperparathyroidism
A. Hemangioblastoma
Meningiomas of CPA present with which of the following?
● A. Early facial nerve involvement
● B. Early hearing loss
● C. Less trigeminal neuralgia like pain than VS
● D. Tinnitus
● E. Rarely calcified
A. Early facial nerve involvement
Which of the following features favor nasal glioma in contrast to encephalocele?
● A. Pulsatile
● B. Positive Furstenberg sign
● C. Absence of stalk
● D. Probe can be passed laterally
● E. Presence of hypertelorism
C. Absence of stalk
Which of the following are the non-neoplastic thalamic lesions in pediatric and adult patients?
● A. Cavernous angioma
● B. Granuloma
● C. Heterotopias
● D. AVM
● E. Hamartoma
E. Hamartoma
A patient presents with 2 months history of short-term memory deficit, seizures, and psychiatric symptoms of anxiety, depression, and behavioral changes. His MRI shows bilateral abnormalities highly restricted to medial temporal lobes on T2
FLAIR and CSF shows pleocytosis: WBCs > 5/mm3. On EEG, epileptic or slow-wave activity involving the temporal lobes is seen. What is the most likely diagnosis?
● A. Mesial temporal sclerosis
● B. Herpes encephalitis
● C. Autoimmune limbic encephalitis
● D. Temporal hamartoma
● E. PCA ischemic infarct
C. Autoimmune limbic encephalitis
By the rule of thumb “the differential diagnosis of a
solitary intraparenchymal lesion in an adult posterior fossa is metastasis, metastasis, metastasis until proven otherwise.” Other differential diagnoses in P-fossa of adults include hemangioblastoma, cerebellar astrocytoma, brainstem glioma, choroid plexus tumor, cerebellar liponeurocytoma, abscess, cavernous hemangioma, or hemorrhage. Differential in pediatric posterior fossa includes medulloblastoma (27%), cerebellar astrocytoma (27%), brain stem gliomas (28%), ependymoma, choroid plexus papilloma, and metastasis. How can medulloblastoma be differentiated from ependymoma?
● A. Medulloblastoma arise from the roof of the 4th ventricle and most are solid while ependymoma arise from the floor of the 4th ventricle
● B. The 4th ventricle drapes around the medulloblastoma forming “banana sign” while ependymoma tends to grow through the foramen of Luschka or/and Magendie
● C. Ependymoma tends to homogenous on T1WI while medulloblastoma tends to be heterogenous
● D. The exophytic component of ependymomas tends to be high signal on T2WI MRI while medulloblastoma is only mildly hyperintense
● E. Calcifications are more common in ependymomas while in MB these are less than 10%
● F. All of the above
F. All of the above
What is the most common cerebellopontine (CP) angle lesion among the following CP angle lesions listed below?
● A. Vestibular schwannoma
● B. Meningioma
● C. Epidermoid
● D. Arachnoid cyst
● E. Trigeminal neuroma or facial nerve neuroma
A. Vestibular schwannoma
How can vestibular schwannoma be differentiated from meningioma in CP angle region?
● A. VS presents with progressive unilateral hearing loss usually with tinnitus, and facial nerve signs and symptoms occur late. In case of CP angle meningioma, early facial nerve involvement is more common, and hearing loss is usually late
● B. Trigeminal neuralgia like pain is more common with CP angle meningioma as compared to VS
● C. On imaging VS shows heterogenous signal and nonuniform enhancement while VP angle meningioma shows homogenous signal and enhancement
● D. Medium size tumor in case of VS look like ice cream in the cone (trumpet sign) with the tumor forming an acute angle between the tumor and petrous bone and enlargement of IAC is often present while in case of meningioma, IAC is usually not enlarged with the tumor flat against the petrous bone forming an obtuse angle with the bone
● E. Calcifications and bony hypertrophy may occur in case of meningioma while in case of VS these are often absent
● F. All of the above
F. All of the above
A patient presents in neurosurgical OPD with complaints of craniocervical junction pain in the neck and occiput with increase in pain with increased head movement. This patient also has numbness and tingling in fingers with dissociated sensory loss (loss of pain and temperature contralateral to the lesion with preservation of tactile sensation). There is spastic weakness of the extremities which usually starts in the ipsilateral
upper limb, then the ipsilateral lower limb, then the contralateral lower limb, and finally contralateral upper limb (rotatory paralysis). Following are the differential diagnosis of foramen magnum lesion except?
● A. Meningioma
● B. Chordoma
● C. Ependymoma
● D. Neurilemmoma
● E. Epidermoid
● F. Chondroma
● G. Chondrosarcoma
C. Ependymoma
Enhancing ring of tumor may be incomplete and irregular while in case of abscess, the ring is usually complete, often thinner and smoother than the tumor. Abscess is usually brighter than the tumor on DWI MRI. MR spectroscopy is ideal for differentiating the tumor from the abscess with the abscess
showing reduced NAA, Cr, and choline while the tumor shows increased choline peak. What are the differential diagnoses in case of ring-enhancing lesions?
● A. Metastasis (including lymphoma)
● B. Abscess
● C. Glioma (astrocytoma usually glioblastoma)
● D. Infarct
● E. Contusion
● F. Demyelination
● G. Radiation
● H. All of the above
H. All of the above
Differential diagnosis of tumors in sellar, suprasellar, or parasellar region includes pituitary tumors (adenohypophyseal tumors and neurohypophyseal tumors), pituitary pseudotumors (thyrotroph hyperplasia, gonadotroph hyperplasia, somatotroph hyperplasia), juxtasellar or suprasellar tumors, or masses (craniopharyngioma, Rathke cleft cyst, meningioma, germ cell tumors, hypothalamic tumors, optic nerve or chiasma tumors). Which of the following are the differentiating points between
hypophysitis and adenoma?
● A. Enlargement of hypophyistis is symmetric while in case of adenoma it is asymmetric
● B. Pituitary stalk is thickened and nontapering in case of hypophysitis while it is not thickened, tapering, and deviated in case of adenoma
● C. Sellar floor is spared in hypophysitis while it may be eroded in case of tumor
● D. Enhancement is intense and may be heterogenous in case of adenoma, while it is less intense and usually homogenous in case of hypophysitis
● E. Mean size at the time of presentation of hypophysitis is 3-cm cube in case of hypophysitis, while it is 10-cm cube in case of adenoma
D. Enhancement is intense and may be heterogenous in case of adenoma, while it is less intense and usually homogenous in case of hypophysitis
Differential of orbital tumors in adults include neoplastic lesions (cavernous hemangioma, capillary hemangioma, lymphangioma, melanoma, retinoblastoma, lymphoma), congenital lesion (retinopathy of prematurity, persistent hyperplastic
primary vitreous), infectious, inflammatory, and vascular lesions. What is the most common orbital lesion in pediatric patients among the following?
● A. Dermoid cyst
● B. Hemangioma
● C. Rhabdomyosarcoma
● D. Optic nerve glioma
● E. Lymphangioma
A. Dermoid cyst
Following statements are correct regarding the type of intraventricular lesion by location except?
● A. Meningioma is the most common tumor in the atrium of lateral ventricle (trigone) in adults more than 30 years of age while in case of children less than 5 years of age, choroid plexus papilloma is the most common lesion at this location
● B. Astrocytoma is the most common lesion in the frontal horn of ventricle and then meningioma
● C. At the foramen of Monro region, SEGAs are most common in people 6 to 30 years of age with pilocytic astrocytoma in the second and CPP in the third number at this location, while in case of adults more than 30 years, metastasis is the most common tumor at this location
● D. The most common lesion at the 3rd ventricle is colloid cyst, then craniopharyngioma, and then astrocytoma
● E. Epidermoid is the most common lesion in the 4th ventricle and then comes medulloblastoma and ependymoma
E. Epidermoid is the most common lesion in the 4th ventricle and then comes medulloblastoma and ependymoma
What is the most common periventricular solid enhancing lesion?
● A. Ependymoma
● B. Lymphoma
● C. Metastatic carcinoma
● D. Ventriculitis
● E. Medulloblastoma
B. Lymphoma
How can an encephalocele be differentiated from nasal glioma?
● A. Encephalocele is frequently pulsatile while nasal glioma is nonpulsatile
● B. Encephalocele swells with Valsalva maneuver while nasal glioma does not
● C. Presence of hypertelorism suggests encephalocele while it does not correlate with nasal glioma
● D. Probe can be passed lateral to encephalocele while it cannot be passed lateral to a nasal glioma
● E. Encephalocele is attached to the CNS with a stalk while nasal glioma does not
● F. All of the above
F. All of the above
Atlantoaxial subluxation in rheumatoid arthritis is due to which of the following?
● A. Erosion of insertion points of the TAL
● B. Congenital laxity of the TAL
● C. Disruption (tear) of the TAL
● D. Avulsion of the insertion points of the TAL
● E. Incompetence of the odontoid process
A. Erosion of insertion points of the TAL
Fractures due to metastatic involvement show which of the following?
● A. Hyperintense on T1WI and hyperintense on T2WI
● B. Hypointense on T1WI and hyperintense on T2WI
● C. Isointense on T1WI and hypointense on T2WI
● D. Hypointense on T1WI and hypointense on T2WI
● E. Hyperintense on T1WI and hypointense on T2WI
B. Hypointense on T1WI and hyperintense on T2WI
Criteria for vertebra plana include all of the following except?
● A. Increased density of vertebra
● B. Spares neural arches
● C. Normal disk and intervertebral disk space
● D. Intervertebral vacuum cleft sign
● E. Kyphosis
E. Kyphosis
Destruction of the disk space which often involves at least two adjacent vertebral levels is highly suggestive of which of the following?
● A. Tumor
● B. Potts disease
● C. Pyogenic infection
● D. Metastasis
● E. None of the above
C. Pyogenic infection
What is the most common sacral neoplasm?
● A. Chordoma
● B. Osteoma
● C. Metastasis
● D. Giant cell tumor
● E. Teratoma
C. Metastasis
In which type of sacral agenesis, there is partial bilaterally symmetric defects in the sacrum, iliac bones articulate with S1, and distal segments of the sacrum and coccyx fail to develop?
● A. Type 1
● B. Type 2
● C. Type 3
● D. Type 4
● E. Type 5
B. Type 2
Nodular enhancing lesions in spine occur in all of the following except?
● A. Neurofibromatosis
● B. Drop metastasis
● C. Meningioma
● D. Schwannoma
● E. Neurofibroma
C. Meningioma
Which of the following is the cause of atlantoaxial subluxation?
● A. Incompetence of transverse atlantal ligament (TAL) which can be due to rheumatoid arthritis (causes erosion of insertion point of TAL), traumatic, congenital laxity of TAL (in Down syndrome), retropharyngeal infection, or chronic steroid use
● B. Incompetence of odontoid process which can be due to odontoid fractures, os odontoideum, erosion of odontoid due to rheumatoid arthritis, neoplastic erosion of odontoid (metastasis), local infection, or congenital absence
● C. Congenital absence of tectorial membrane
● D. Basilar invagination
● E. Both A and B
E. Both A and B
Which of the following are the etiologies of pathologic fracture of spine?
● A. Osteoporosis
● B. Neoplasm (metastasis, lymphoma, hemangioma)
● C. Infection
● D. Avascular necrosis of vertebral bodies (with excessive use of steroids)
● E. All of the above
E. All of the above
All of the following are destructive lesions of spine except?
● A. Neoplastic (metastatic or primary bone tumors like chordoma, osteoid osteoma, hemangioma)
● B. Paget’s disease
● C. Infection like vertebral osteomyelitis
● D. Ankylosing spondylitis
● E. Chronic renal failure causing spondyloarthropathy resembling infection
B. Paget’s disease
Following are the causes of vertebral hyperostosis except?
● A. Paget’s disease
● B. Osteoblastic metastasis (prostate in men and breast in women)
● C. Marfan’s syndrome or Ehlers Danlos syndrome
● D. Osteoid osteoma or osteoblastoma
● E. Bone island (also known as enostosis)
C. Marfan’s syndrome or Ehlers Danlos syndrome
Which of the following is the most common sacral neoplasm?
● A. Metastasis
● B. Giant cell tumor
● C. Chordoma
● D. Teratoma
● E. None of the above
A. Metastasis
Sacral agenesis is associated with increased incidence of spinal abnormalities like syrinx, tethered cord, lipoma, and lipomyelomeningocele. Which of the following are the types of sacral agenesis?
● A. Type 1: partial unilateral agenesis
● B. Type 2: partial bilaterally symmetric defects in the sacrum
● C. Type 3: total sacral agenesis plus iliac bone fuses with the lowest segment of the lumbar spine present
● D. Type 4: total sacral agenesis plus iliac bones fuse posteriorly in the midline
● E. All of the above
E. All of the above
Following are the causes of enhancing nerve roots except?
● A. Tumor (meningeal carcinomatosis and lymphoma)
● B. Infection (CMV)
● C. Inflammatory (Guillain–Barre, arachnoiditis)
● D. Neurofibromatosis
D. Neurofibromatosis
Which of the following are the differential of nodular enhancing lesions in the spinal canal?
● A. Neurofibromatosis
● B. Drop metastasis
● C. Neurofibroma
● D. Schwannoma
● E. All of the above
E. All of the above
Which of the following are the differentials of intraspinal cysts?
● A. Spinal meningeal cysts
● B. Cystic neurofibroma
● C. Ependymoma
● D. Syringomyelia
● E. Dilated central canal
● F. All of the above
F. All of the above
Which of the following are the differentials of diffuse enhancement of nerve roots/cauda equina?
● A. Guillain Barre
● B. Meningitis
● C. CMV
● D. Lymphoma
● E. Sarcoid
● F. All of the above
F. All of the above
What is the most common cause of syncope?
● A. Reflex-mediated such as vasovagal or Valsalva/stress-induced
● B. Cardiac valvular etiology or arrhythmia
● C. Orthostatic due to autonomic dysregulation, dehydration, or polypharmacy
● D. Cerebrovascular due to stroke
● E. Seizure
A. Reflex-mediated such as vasovagal or Valsalva/stress-induced
Most of transient ischemic attack (TIA) resolve within how long?
● A. < 5 minutes
● B. < 10 minutes
● C. < 20 minutes
● D. < 30 minutes
● E. < 40 minutes
C. < 20 minutes
Wide base gait is defined as gait with feet spread of how much?
● A. > 1 to 2 inch apart
● B. > 2 to 4 inch apart
● C. > 4 to 6 inch apart
● D. > 6 to 8 inch apart
● E. > 8 to 10 inch apart
B. > 2 to 4 inch apart
A patient presented with abdominal cramps, dry mouth, and diarrhea followed by symmetrical cranial nerve palsies, diplopia, ptosis, loss of accommodation, and pupillary light reflex and descending weakness. Sensory disturbances are absent. Sensorium is clear. What is the most likely diagnosis?
● A. Graves’ disease
● B. Myasthenia gravis
● C. Giant cell arteritis
● D. Botulism
● E. Pseudotumor cerebri
D. Botulism
All of the following are causes of facial diplegia except?
● A. Mobius syndrome
● B. Guillain Barre syndrome
● C. Lyme disease
● D. Lhermitte Duclos syndrome
● E. Sarcoidosis
D. Lhermitte Duclos syndrome
A 30-year-old patient presented with binocular vision loss after head trauma. All of the following are causes of binocular vision loss except?
● A. Amaurosis fugax
● B. Bilateral PCA flow impairment
● C. Bilateral occipital lobe injury
● D. Raised ICP
● E. Epileptic blindness
A. Amaurosis fugax
Exophthalmos is defined as anterior displacement of globe by how much?
● A. > 14 mm
● B. > 16 mm
● C. > 18 mm
● D. > 20 mm
● E. > 22 mm
C. > 18 mm
What is the most common cause of unilateral proptosis?
● A. Orbital tumor
● B. Infection (cellulitis)
● C. Hemorrhage
● D. Thyroid disease
● E. Cavernous sinus occlusion
D. Thyroid disease
Which of the following investigations is not helpful for diagnosis (nonsensitive, nonspecific) of pulsatile tinnitus?
● A. MRI
● B. MRV
● C. Carotid USG
● D. Angiogram
● E. None of the above
C. Carotid USG
How frequently is treatment required for arachnoid cyst?
● A. 10%
● B. 20%
● C. 30%
● D. 40%
● E. 50%
C. 30%
Syncope is defined as one or more episodes of brief loss of consciousness with prompt recovery. Which of the following are the etiologies of syncope?
● A. Cerebrovascular (subarachnoid hemorrhage, intracerebral hemorrhage, brainstem infarction, pituitary apoplexy, vertebrobasilar insufficiency, rarely with migraine)
● B. Cardiovascular (carotid sinus syncope, vasopressor syncope, cardiac standstill, orthostatic hypotension)
● C. Infections (meningitis, encephalitis)
● D. Metabolic hypoglycemia
● E. All of the above
E. All of the above
Following are the causes of transient neurologic deficit except?
● A. Transient ischemic attack
● B. Migraine
● C. Spinocerebellar degeneration
● D. Seizures
● E. TIA like syndrome (tumor TIA)
C. Spinocerebellar degeneration
Wide based gait is a gait with feet spread more than 2 to 4 inches apart. Which of the following are included in the differentials of this symptom?
● A. Idiopathic normal pressure hydrocephalus
● B. Cerebellar ataxia
● C. Sensorimotor peripheral neuropathy
● D. Vestibular ataxia
● E. Myelopathy
● F. All of the above
F. All of the above
Following are the causes of diplopia except?
● A. Cranial nerve palsy of any one or a combination of cranial nerves 3, 4, and 6
● B. Intraorbital mass compressing extraocular muscles
● C. Grave’s disease
● D. Myasthenia gravis
● E. Friderichsen syndrome
● F. Giant cell arteritis
E. Friderichsen syndrome
Following are included in the most probable cause of gradual onset of anosmia except?
● A. Allergic rhinitis and sinus disease
● B. Intracranial neoplasms
● C. Head trauma
● D. Nasal polyps
● E. Intracranial neoplasms like olfactory groove meningioma
C. Head trauma
Marble bone disease is a group of genetic disorders of defective osteoclastic resorption of bone resulting in increased bone density, which may be transmitted either as autosomal dominant or recessive. What is the other name of this disease?
● A. Paget’s disease
● B. Marfan syndrome
● C. Osteopetrosis
● D. Osteoporosis
● E. None of the above
C. Osteopetrosis
All of the following are included in the differentials of binocular blindness except?
● A. Bilateral posterior cerebral artery flow impairment
● B. Amaurosis fugax due to giant cell arteritis or TIAs
● C. Bilateral vitreous hemorrhage
● D. Trauma with bilateral occipital lobe injury
● E. Posterior ischemic optic neuropathy usually in the setting of shock
B. Amaurosis fugax due to giant cell arteritis or TIAs
Exophthalmos is abnormal protrusion of eyeball. It can be pulsatile or nonpulsatile. All of the following are included in nonpulsatile exophthalmos except?
● A. Intraorbital tumors like optic glioma, optic sheath neuroma, lymphoma or Graves disease or enlargement of periorbital fat
● B. Carotid cavernous fistula or transmitted intracranial pulsations due to defect in orbital roof or vascular tumors
● C. Inflammatory or hemorrhage or third nerve palsy
● D. Cavernous sinus occlusion
● E. Pseudo exophthalmos
B. Carotid cavernous fistula or transmitted intracranial pulsations due to defect in orbital roof or vascular tumors
Ptosis is drooping of upper eyelid. Ptosis can be pupil sparing or not pupil sparing. Etiologies of pupil sparing ptosis includes the following except?
● A. Congenital
● B. Traumatic injury to eyelid or traumatic roof fracture
● C. Neurogenic involving third nerve palsy due to compression from tumors or pituitary apoplexy
● D. Myogenic ptosis due to botulism toxin or myasthenia gravis
● E. None of the above
C. Neurogenic involving third nerve palsy due to compression from tumors or pituitary apoplexy
Following are the causes of macrocephaly with ventricular enlargement except?
● A. Hydranencephaly
● B. Constitutional ventriculomegaly
● C. External hydrocephalus
● D. Hydrocephalus ex vacuo
● E. Obstructive hydrocephalus
C. External hydrocephalus
Which one of the following does not present as a spinal epidural mass?
● A. Bone fracture
● B. Extramedullary hematopoiesis
● C. Vertebral Paget disease
● D. Bony compression secondary to incompetence of odontoid process or transverse atlantal ligament
● E. Cervical or thoracic spinal stenosis
E. Cervical or thoracic spinal stenosis
A 17-year-old male patient presents with insidious asymmetrical painless wasting of the distal UE muscles. What is the most likely diagnosis?
● A. Epidural lipomatosis
● B. Vertebral Paget disease
● C. OPLL
● D. Hirayama disease
● E. Idiopathic spinal cord herniation
D. Hirayama disease
All are signs of ALS except?
● A. It is an upper and lower motor neuron disease
● B. Slight spasticity of LEs
● C. Atrophic weakness of the hands and forearms
● D. Fasciculations in the UE
● E. Loss of sphincter control
E. Loss of sphincter control
What is the most common cause of sciatica?
● A. Diskitis
● B. Spinal stenosis
● C. Lumbar disk herniation
● D. Tumor
● E. None of the above
C. Lumbar disk herniation
A patient presents with pain in the sciatic distribution and weakness of external rotation and abduction of the hip. On clinical examination, Freiberg test and Pace test are positive.
What is the most likely diagnosis?
● A. Piriformis syndrome
● B. Femoral neuropathy
● C. Diabetic neuropathy
● D. Sacral tumor
● E. Herniated lumbar intervertebral disk
A. Piriformis syndrome
What is the most common etiology of pure motor hemiplegia?
● A. Ischemic lacunar infarct
● B. Tumor of motor strip
● C. Brainstem ischemic infarct
● D. Foramen magnum lesions
● E. Acute subdural hematoma
A. Ischemic lacunar infarct
Which of the following conditions presents with descending paralysis with ophthalmoplegia?
● A. Guillain-Barre syndrome
● B. Tick borne paralysis
● C. Myasthenia gravis
● D. Spinal infections
● E. Ascending hematomyelia
D. Spinal infections
In sacral plexus lesions, which of the following muscles will be spared on EMG?
● A. Gluteus maximus
● B. Gluteus medius
● C. Gluteus minimus
● D. Piriformis
● E. Both A and B
E. Both A and B
Which of the following feature suggests L4 radiculopathy?
● A. Iliopsoas weakness
● B. Quadriceps weakness
● C. Preservation of power in thigh adductors
● D. Sensory loss in anterior thigh
● E. Intact sensations from knee to medial malleolus
B. Quadriceps weakness
In patients with foot drop, which of the following muscles must be spared to differentiate common peroneal nerve palsy from L4–L5 radiculopathy?
● A. Anterior tibialis
● B. Posterior tibialis
● C. Extensor digitorum longus
● D. Extensor hallucis longus
● E. None of the above
B. Posterior tibialis
Which of the following is not an etiology of Lhermitte’s sign?
● A. Multiple sclerosis
● B. Cervical spondylosis
● C. Subacute combined degeneration
● D. Central cord syndrome
● E. Anterior cord syndrome
E. Anterior cord syndrome
All of the following are the congenital causes of myelopathy except?
● A. Arnold Chiari malformation
● B. Tethered cord or syringomyelia
● C. Cervical or thoracic spine stenosis
● D. Neurenteric cyst or hereditary spastic paraplegia
● E. Cord compression that occurs with some mucopolysaccharidoses
C. Cervical or thoracic spine stenosis
Which of the following are the possible causes of myelopathy?
● A. Congenital
● B. Acquired
● C. Neoplastic (primary spine tumors, carcinomatous meningitis, or epidural metastasis)
● D. Vascular (spinal cord infarction, vascular malformation)
● E. All of the above
E. All of the above
Causes of sciatica include congenital (meningeal cyst, conjoined nerve root), acquired (spinal stenosis, juxtafacet cyst, nerve root sheath cyst), infections, neoplastic, inflammatory, and vascular. What is the most common cause of sciatica?
● A. Radiculopathy due to herniated lumbar disk
● B. Bone or soft tissue tumors along the course of sciatic nerve
● C. Diskitis
● D. Spinal stenosis, spondylosis/spondylolysis/spondylolisthesis
● E. Nerve root sheath cyst
A. Radiculopathy due to herniated lumbar disk
Which of the following are the points to differentiate femoral neuropathy from L4 radiculopathy?
● A. Distribution of sensory loss in femoral neuropathy is anterior thigh, while in case of L4 radiculopathy, it is dermatome from knee to medial malleolus sparing anterior thigh
● B. Iliopsoas is weak in case of femoral neuropathy while it is normal in case of L4 radiculopathy
● C. Thigh adductors are normal in case of femoral neuropathy while it may be weak in case of L4 radiculopathy
● D. Quadriceps are weak in case of both femoral neuropathy and in L4 radiculopathy
● E. All of the above
E. All of the above
Following are the possible causes of acute paraplegia or quadriplegia except?
● A. In infancy spinal muscular atrophy, spinal cord injury, congenital myopathies, infantile botulism
● B. Traumatic spinal cord injury
● C. Congenital (achondroplasia, syringomyelia)
● D. Spinocerebellar degeneration
● E. Metabolic (thallium poisoning, central pontine myelinolysis)
● F. Infections
● G. Peripheral neuromuscular disorders (GBS, myopathies)
D. Spinocerebellar degeneration
Following are the causes of hemiplegia or hemiparesis due to insult within the brain except?
● A. Lesions of the contralateral internal capsule
● B. Lesions of the brain stem
● C. Lesions of the cervicomedullary junction
● D. Unilateral spinal cord lesion
● E. Brain tumor or traumatic epidural or subdural hematoma
D. Unilateral spinal cord lesion
Which of the following are the differentials of ascending paralysis?
● A. GBS
● B. Tick-borne paralysis
● C. Spinal infection
● D. Patients with a prior spinal cord injury which can be due to ascending hematomyelia or post-traumatic syringomyelia
● E. All of the above
E. All of the above
Chronic low-back pain is pain in back after 3 months. What are the causes of chronic low-back pain?
● A. Degenerative conditions like spinal stenosis, degenerative spondylolisthesis
● B. Spondyloarthropathies like ankylosing spondylitis
● C. Osteitis condensans ilii which is increased density in the ilium which is usually found in pregnant women
● D. Psychological overlay
● E. All of the above
E. All of the above
Foot drop is because of weakness of anterior tibialis muscle which is innervated by deep peroneal nerve. What is the most common cause of foot drop?
● A. L4/L5 radiculopathy
● B. Common peroneal nerve palsy
● C. Parasagittal lesion in the brain
● D. Lumbosacral plexus neuropathy
● E. Muscular dystrophy
A. L4/L5 radiculopathy
Lhermitte’s sign is electric shock like sensation radiating down the spine usually provoked by neck flexion. Which of the following are the etiologies in which this sign can be positive?
● A. Multiple sclerosis
● B. Cervical spondylosis
● C. Cervical cord tumor
● D. Cervical disk herniation
● E. Chiari type 1 malformation
● F. All of the above
F. All of the above
Owing to risk of developing paraparesis, quadriplegia, multiple cranial nerves, dementia, and hydrocephalus, which of the following dyes must not be used as stain in neurosurgical procedures?
● A. Indigo carmine
● B. Methylene blue
● C. Flourescien
● D. Indocyanine green
● E. Gentian violet
B. Methylene blue
For children below 3 years of age, the knob of Mayfield head holder clamp housing the tension spring and gauge is tightened up to how much?
● A. 20 to 30 lbs
● B. 30 to 40 lbs
● C. 40 to 50 lbs
● D. 50 to 60 lbs
● E. Not applicable
E. Not applicable
Microfibrillar collagen promotes adhesion and aggregation of platelets and leads to chemical hemostasis. It is rendered ineffective if platelets count is how much?
● A. < 50,000/mL
● B. < 40,000/mL
● C. < 30,000/mL
● D. < 20,000/mL
● E. < 10,000/mL
E. < 10,000/mL
Which of the following is an important imaging view of MRI to identify L5–S1 disk space for preoperative localization of level by identifying sacral ala?
● A. Sagittal view
● B. Coronal view
● C. Axial view
● D. Both A and B
● E. Both A and C
C. Axial view
If best osteoconductive and osteogenic properties are required, which bone graft is preferable?
● A. Cancellous bone graft
● B. Cortical bone graft
● C. Vascularized autograft
● D. Bone marrow aspirate
● E. Devascularized bone graft
A. Cancellous bone graft
Bone growth stimulators are indicated to be used in all of following conditions except?
● A. Diabetes
● B. Inflammatory arthritis
● C. Systemic vascular disease
● D. Malignancy
● E. Cigarette smokers
D. Malignancy
Which of the following dural substitutes is absorbable, retains suture, and can be used with dural sealant?
● A. Tutopatch®
● B. Neuro-Patch®
● C. DuraGen®
● D. Durepair®
● E. DuraMatrix®
A. Tutopatch®
What is the lateral limit of safe region for posterior iliac crest bone graft in order to protect superior cluneal nerves crossing iliac crest?
● A. 3 cm
● B. 5 cm
● C. 6 cm
● D. 8 cm
● E. 9 cm
D. 8 cm
Indigo carmine is a blue dye that can be used intrathecally to locate CSF leaks. Fluorescein is another dye which can be used intrathecally or IV. Fluorescein is used in diluted form because it can cause which of the following side effects?
● A. Brain stem herniations
● B. Increased ICP
● C. Seizures
● D. Blindness
● E. Memory impairment
C. Seizures
A patient is given IT dye after which he/she develops quadriplegia, multiple cranial nerve palsy, dementia, and hydrocephalus. Which dye is given to this patient?
● A. Indigo carmine
● B. Methylene blue
● C. Fluorescein
● D. Indigo cyanine
● E. Ultravist
B. Methylene blue
For spine cases, the ideal location of observer’s eye piece is directly opposite the surgeon. For intracranial work, the observer’s eye piece is placed to the right of the operators except in which of the following cases where it is placed to the left?
● A. Transsphenoidal surgery
● B. Right posterior fossa craniotomy in lateral oblique position
● C. For supine position surgery with head tilt toward one side
● D. For craniotomy of posterior fossa in prone position
● E. Both A and B
E. Both A and B
Pin-based head fixation include the Mayfield head holder or head frame. Following are the indications for pin stabilization except?
● A. Craniotomy for most intracranial vascular operations
● B. Craniotomy for most tumor operations especially if there is need of retractor system that attaches to the Mayfield head holder
● C. When intraoperative image guidance system is used
● D. For craniotomy in patients less than 3 years of age
● E. In cervical spine often used for posterior cervical operations
D. For craniotomy in patients less than 3 years of age
Which of the following are the complications of pin head fixation?
● A. Malposition of pins through unintended anatomic structure like pinna, orbit, superficial artery, or poor fixation by not properly placing pins close to the equator
● B. Skin penetration by pins which can cause injury to intracranial structures
● C. Skin necrosis or skull fracture
● D. Slippage of any of the joints or connections to the OR table or clamp breakage or bleeding from pin site
● E. All of the above
E. All of the above
All of the following are included in the mechanical means of hemostasis except?
● A. Bone wax use
● B. Ligature
● C. Use of monopolar or bipolar cautery
● D. Use of silver clips (hemoclips)
● E. None of the above
C. Use of monopolar or bipolar cautery
All of the following are means of chemical hemostasis except?
● A. Gelatin sponge
● B. Oxidized cellulose
● C. Bone wax
● D. Microfibrillar collagen
● E. Thrombin
C. Bone wax
All of the following are included in the allograft for use as dural substitutes except?
● A. Reconstituted material like processed gelatin
● B. Processed intact natural materials like ovine or bovine
● C. Fascia lata or galea or pericranium
● D. Synthetic materials like polyesterurethane
● E. Biosynthetic materials like cellulose
C. Fascia lata or galea or pericranium
Which of the following are the components of bone graft that are important for fusion?
● A. Osteoinduction which is recruitment of mesenchymal cells and the stimulation of these cells to develop into osteoblast or osteoclasts
● B. Osteogenesis which is formation of new bone by host or graft mesenchymal stem cells
● C. Osteoconduction which is the structure of the graft that acts as a scaffold upon which new bone and blood vessels form
● D. Mechanical stability which is the structural anatomical biomechanical support
● E. All of the above
E. All of the above
Which of the following bone graft material has the best osteogenic property?
● A. Cancellous graft
● B. Cortical autograft
● C. Bone marrow aspirate
● D. Vascularized autograft
● E. Demineralized bone matrix
A. Cancellous graft
Intraoperative brain swelling etiologies include all of the following except?
● A. Extraparenchymal bleeding: from a vessel or intraoperative aneurysm rupture
● B. Intracerebral hemorrhage
● C. Venous outflow obstruction
● D. Vasodilatation induced by hypocarbia
● E. Severe diffuse cerebral edema
D. Vasodilatation induced by hypocarbia
What is the last life-saving measure for uncontrollable intraoperative brain swelling?
● A. Reverse Trendelenburg position
● B. Removal of swollen brain
● C. Decompressive craniectomy
● D. Apply pressure on the brain
● E. Place the head in neutral position
B. Removal of swollen brain
Cranioplasty following posterior fossa surgery for vestibular schwannoma reduced the incidence of postoperative headache to how much?
● A. 4%
● B. 17%
● C. 50%
● D. 70%
● E. 100%
A. 4%
What is the incidence of postoperative headache after posterior fossa surgery?
● A. 100%
● B. 80%
● C. 95%
● D. 97%
● E. 90%
B. 80%
A patient who underwent tumor resection and awake craniotomy develops lethargy, confusion, severe headache, nausea, vomiting, and seizures. For awake craniotomy, skull block is being done for which local anesthetic agents injection must be applied at many regions?
● A. 1 region
● B. 2 regions
● C. 3 regions
● D. 4 regions
● E. 5 regions
D. 4 regions
Definitive treatment of syndrome of trephination is indicated if headache does not settle within how long?
● A. 2 months
● B. 3 months
● C. 4 months
● D. 5 months
● E. 6 months
B. 3 months
During awake craniotomies, what is the maximum current that can be used to stimulate any area of cortex?
● A. 2 mA
● B. 4 mA
● C. 6 mA
● D. 8 mA
● E. 10 mA
E. 10 mA
Which of the following nerves must not be anesthetized during awake craniotomies?
● A. Supraorbital nerve
● B. Facial nerve
● C. Postauricular nerve
● D. Lesser occipital nerve
● E. Third occipital nerve
B. Facial nerve
During awake craniotomy, total speech arrest occurs by stimulating which area of nondominant hemisphere?
● A. Pars opercularis
● B. Frontal operculum
● C. Posterior middle temporal gyrus
● D. Anterior supramarginal gyrus
● E. None of the above
A. Pars opercularis
Which of the following is a contraindication of awake craniotomy?
● A. Thalamic tumor
● B. Epileptic foci in eloquent brain area
● C. Removal of brainstem tumors
● D. Tumor near motor strip
● E. Significant speech/motor deficits
E. Significant speech/motor deficits
The FDA released a number of recommendations for use of drill to reduce injury during craniotomy which are the following?
● A. Selection of appropriate perforator based on the skull thickness (pediatric vs. adults)
● B. Keeping the perforator perpendicular to the skull throughout the drilling process
● C. Do on rock, rotate, or change the angel of the device during drilling
● D. Avoid using excessive pressure on the drill
● E. Use caution when drilling through areas of irregular bone contour, curvature, or variations in thickness or drilling where bone might be diseased or incompetent
● F. All of the above
F. All of the above
All of the following are etiologies of intraoperative brain swelling except?
● A. Extraparenchymal bleeding from a vessel or intraoperative aneurysm rupture
● B. Intracerebral hemorrhage
● C. Venous outflow obstruction
● D. Vasoconstriction induced by hypercapnia
● E. Severe diffuse cerebral edema following stroke or traumatic brain injury
D. Vasoconstriction induced by hypercapnia
Management of intraoperative brain swelling include finding out the cause and treating that cause. Other measures that should be taken for decreasing brain swelling include which of the following?
● A. Elevation of head of bed
● B. Making sure the jugular veins are not kinked
● C. Ruling out hypercarbia, making sure that endotracheal tube is not kinked, and checking the patient’s end tidal pCO2
● D. Measures to lower ICP are adopted, which includes giving mannitol, draining CSF, tapping and draining ventricle, having the anesthesiologist hyperventilate the patient’s pCO2 to 30 to 35 mmHg
● E. Emergency intubation for patients are undergoing awake craniotomy and intraoperative ultrasound or CT of brain
● F. All of the above
F. All of the above
The overall risk of postoperative hemorrhage is 0.8 to 1.1%. Which hematomas constitute 43 to 60% of these?
● A. Intraparenchymal
● B. Epidural
● C. Subdural
● D. Intrasellar
● E. Mixed
A. Intraparenchymal
What are the postoperative medications that are given to a patient after craniotomy for brain tumor?
● A. Dexamethasone and H2 antagonist
● B. Antiepileptic drugs
● C. Cardene drip to keep systolic BP less than 160 mmHg and diastolic BP less than 100 mmHg
● D. Prophylactic antibiotics are continued
● E. Acetaminophen and codeine are also given for pain relief
● F. All of the above
F. All of the above
All of the following are causes of postoperative deterioration of patients after craniotomy except?
● A. Hematoma or cerebral infarction (from compromise of normal arteries or veins)
● B. Postoperative seizures or acute hydrocephalus
● C. Syringomyelia formation
● D. Pneumocephalus or brain edema
● E. Persistent anesthetic effect or vasospasm
C. Syringomyelia formation
What are the causes of postoperative headache in a patient after craniotomy?
● A. Traction of the dura when the bone is not replaced
● B. Traction on dura due to tight dural closure
● C. Temporalis or nuchal muscle dissection
● D. Nerve entrapment in the closing suture or healing scar
● E. Intradural blood and/or CSF leak
● F. All of the above
F. All of the above
Phase reversal technique can be used to see primary sensory or motor cortex. What is the use of intraoperative cortical mapping in a patient undergoing craniotomy?
● A. Motor strip localization
● B. Sensory cortex localization
● C. Speech centers determination
● D. All of the above
D. All of the above
Indications of awake craniotomy include surgery in eloquent brain area, removal of brain stem tumors, or for some seizure surgery to look for seizure focus. All of the following are contraindications of awake craniotomy except?
● A. Patients who are unable to cooperate
● B. Very young or very elderly patients
● C. Confused patients
● D. Those with significant speech deficit already present
● E. Those with no language barrier
E. Those with no language barrier
What is the typical sequence of anesthesia in case of awake craniotomy?
● A. In the preoperative holding area, precedex is started
● B. Induction of anesthesia is given using propofol and skull block is applied
● C. Inhalational anesthesia is started and continued until dura starts to open, at which point inhalational anesthesia is stopped
● D. Remifentanil is given for pain control with neurophysiologic resting performed at this time
● E. Once the intracranial part of the operation is complete, general anesthesia is given again and the operation is completed
● F. All of the following
F. All of the following
Advantages of sitting position for posterior fossa craniotomies include improved drainage of blood and CSF out of the surgical site, enhanced venous drainage which helps reduce venous bleeding, easy ventilation, and patients’ head can be kept at exactly midline. Which of the following are included in the
disadvantages of sitting position?
● A. Possible air embolism
● B. Fatigue of operator’s hand and risk of postoperative hematoma at the surgical site
● C. Possible brachial plexus injury and mid cervical quadriplegia
● D. Extent of postoperative pneumocephalus is more pronounced and venous pooling of blood in the lower extremities
● E. All of the above
E. All of the above
Air embolism is suspected in any operative case in which the surgical site is higher than the heart. Transesophageal echocardiography and precordial Doppler ultrasound are the tests to see air embolism in heart. Following are included in the treatment of air embolism except?
● A. The site of air entry is found and occluded and the patient’s head is lowered if at all possible
● B. Jugular venous compression or aspiration of air from right atrium
● C. Nitrous oxide is given if it is not being used
● D. Patient is ventilated with 100% oxygen
● E. Pressors volume expanders are used to maintain blood pressure
C. Nitrous oxide is given if it is not being used
Lateral oblique position is also known as Park Bench position. Axillary roll is used for the down-side arm and upper arm is supported on pillows or towels. Adhesive tape is used to pull down the upper shoulder. Thorax is usually elevated to what degrees in such cases?
● A. 10 to 15 degrees
● B. 20 to 25 degrees
● C. 30 to 35 degrees
● D. 40 to 45 degrees
● E. It is kept flat
A. 10 to 15 degrees
Indications for paramedian suboccipital craniectomy include all of the following except?
● A. Access to CPA lesions like vestibular schwannoma or for microvascular decompression
● B. For lesions in the cerebellar hemisphere
● C. For access to the posterior communicating artery aneurysms
● D. For access to the vertebral artery for aneurysms or for vertebral endarterectomy
● E. For access to the anterolateral brain stem
C. For access to the posterior communicating artery aneurysms
Which of the following statements are correct regarding access to CP angle lesions through paramedian incision?
● A. A slightly curved retromastoid incision is made 5 mm medial to the mastoid notch
● B. 5–4-6 incision (5 mm medial to mastoid notch, 6 cm above notch, and 4 cm below notch) is made for approach to the fifth nerve like in microvascular decompression
● C. 5–5-5 incision (5 mm medial to mastoid notch, 5 cm above notch, and 5 cm below notch) is used for microvascular decompression for hemifacial spasm or for small vestibular schwannoma
● D. 5–4-6 incision (5 mm medial to notch, 4 cm above notch, and 6 cm below notch) is used for glossopharyngeal neuralgia
● E. All of the above
E. All of the above
For microvascular decompression, a craniectomy of 2 cm is used in the angle between transverse sinus and sigmoid sinus while for small tumors (< 2.5 cm), a 4-cm craniectomy is used in the same space. What are the boundaries of craniectomy for large tumors?
● A. Transverse sinus superiorly
● B. Foramen magnum inferiorly
● C. Sigmoid sinus laterally
● D. Midline medially
● E. All of the above
E. All of the above
Burr hole for placement of emergency ventriculostomy is done at Frazier point which is 3 to 4 cm from midline and how much distance from the inion?
● A. 6 to 7 cm above the inion
● B. 3 to 4 cm above the inion
● C. 6 to 7 cm above the inion in adults, while 3 to 4 cm above inion in children
● D. 8 cm above inion in adults, while 5 cm above inion in children
● E. None of the above
C. 6 to 7 cm above the inion in adults, while 3 to 4 cm above inion in children
For midline suboccipital craniectomies, Y-shaped durotomy is often used and craniectomy is done with no intention of replacing the bone. What is the advantage of not replacing the bone at this location?
● A. It is cumbersome to place bone here
● B. It can dip into cerebellum when the patient lies on head
● C. If there is postoperative swelling, the inelastic bone will cause more pressure to be transmitted to the brainstem
● D. There is more chance of postoperative infection if bone is placed
● E. None of the above
C. If there is postoperative swelling, the inelastic bone will cause more pressure to be transmitted to the brainstem
The two main approaches for the 4th ventricle are transvermian approach and telovelar approach. Following statements are correct regarding these approaches except?
● A. Transvermian approach gives wider and slightly more rostral exposure than telovelar approach
● B. The risks of caudal vermis syndrome, cerebellar mutism, and injury to caudate nucleus are more in case of transvermian approach
● C. No nerve tissue is harmed in case of telovelar approach
● D. Telovelar approach causes decreased access to the lateral recess of the 4th ventricle
● E. Telovelar approach provides narrower corridor as compared to transvermian approach
D. Telovelar approach causes decreased access to the lateral recess of the 4th ventricle
The causes of CSF fistula are abnormal CSF hydrodynamics, poor wound closure, or subarachnoid scarring. The treatment of CSF fistula includes elevation of the head of bed, lumbar
subarachnoid drainage, reinforcement of skin incisions, or surgical correction. What are the treatment options for suboccipital pseudomeningocele?
● A. Noninvasive measures like expectant management, fluid restriction, head wrapping, keeping head of bed elevated, and acetazolamide use
● B. Percutaneous aspiration
● C. Direct surgical exploration with multilayer closure
● D. Lumbar drainage or ventricular drainage
● E. All of the above
E. All of the above
Which of the following is not an ideal indication of pterional craniotomy?
● A. All aneurysms of anterior circulation
● B. Basilar tip aneurysms
● C. Direct surgical approach to cavernous sinus
● D. Primarily sellar PitNET
● E. Craniopharyngioma
D. Primarily sellar PitNET
What is the head rotation required in pterional craniotomy for exposure of Acom artery aneurysm?
● A. 30 degrees from vertical
● B. 45 degrees from vertical
● C. 60 degrees from vertical
● D. 75 degrees from vertical
● E. 90 degrees from vertical
C. 60 degrees from vertical
What must be linear incision for small craniectomy in temporal region for laterally located vestibular schwannoma?
● A. 0.5 cm anterior to the EAC, extending 7 to 8 cm above the zygomatic arch
● B. 1 cm anterior to the EAC, extending 7 to 8 cm above the zygomatic arch
● C. 0.5 cm anterior to the EAC, extending 3 to 4 cm above the zygomatic arch
● D. 2 cm anterior to the EAC, extending 7 to 8 cm above the zygomatic arch
● E. 1.5 cm anterior to the EAC, extending 7 to 8 cm above the zygomatic arch
A. 0.5 cm anterior to the EAC, extending 7 to 8 cm above the zygomatic arch