Section 2B Flashcards
What is gastritis?
Inflammation of the stomach lining
Acute gastritis is most commonly associated with what 4 local irritants?
Bacterial endotoxins
Alcohol
Aspirin
NSAIDS
What are 4 symptoms of acute gastritis
- Anorexia
- Nausea
- Emesis
- Transient pain and usually disappear once the agent is removed
What occurs during chronic gastritis
Atrophy of the glandular epithelium of the stomach
What is the most common form of chronic gastritis
Helicobacter pylori gastritis
What was the accepted medical paradigm to explain ulcers until the early 1980s
That excess acid damaged the gastric mucosa and that treatment should be aimed at reducing or neutralizing that acid. Many clinicians linked overproduction of acid to stress
What allows H. pylori to survive in the stomach?
It survives because it produces the enzyme urease, which generates substances (NH3) that neutralize the stomach’s acid and enable the bacteria to survive
T or F, H. pylori does not penetrate the gastric mucosa
False, It does
Other than H. pylori, what are 3 other risk factors for peptic ulcer disease?
- NSAIDs
- Smoking
- Ethanol
What is a hiatal hernia?
Occurs when a portion of the stomach prolapses through the diaphragmatic or esophageal hiatus
Name 5 predisposing factors of hiatal hernias
- Muscle weakening and loss of elasticity as people age
- More common in women. Pregnancy forces
- Western, fiber-depleted diet leads to chronic constipation and straining during bowel movement
- Obesity because of increased abdominal pressure
- presence of abdominal ascites
T or F, Hiatal hernias do not affect LES function
False, They may compromise LES function
Does a hiatal hernia increase the risk for GERD?
Yes, it may trap a reservoir of gastric contents above the diaphragm
What is the role of Intrinsic factor (IF) that is produced by the stomach?
IF binds to vitamin B12 in the small intestine. The complex is then absorbed by enterocytes of the terminal ileum, from which it is delivered to the bloodstream
What does inadequate absorption of vitamin B12 cause?
Pernicious anemia which is characterized by the appearance in the bloodstream of large primitive RBC precursors called megaloblasts