Secretion Flashcards
How can carrier mediated secretory mechanisms allow the secretion of exogenous substances such as drugs be secreted from the peritubular capillaries into the proximal tubule?
The carrier mediated secretory mechanims are not specific so we are able to use them as transporters for exogenous substances that the body has never been exposed to before
Via which carrier mediated secretory mechanism allows the secretion of substances such as penicillin, aspirin and PAH?
Organic acid mechanism for lactic and uric acid
What carrier mediated secretory system can be used to secret substances such as morphine and atropine?
Organic base mechanisms for choline and creatinine
What effect does hypokalaemia have?
Hypokalaemia increases resting membrane potential, hyperpolarising muscle cells i.e. cardiac muscle = arrhythmias
What affects does hyperkalaemia have?
Hyperkalaemia decreases resting membrane potential of excitable cells = ventricular fibrillation
Where is K primarily absorbed?
Proximal tubule
Where do changes of K secretion occur?
The distal tubule
Does an increase in K cause an increase or decrease in aldosertone and what effect does this have?
Increased plasma K = increased aldosterone = increased K secretion
What is ANP and what is its function?
ANP is anti natriuretic peptide
it is a hormone produced form the heart atrial cells
it inhibits production of renin and therefore reduces BP
