Secondary Lymphoid Organs & Lymphocyte Trafficking

Question 1

B and T cells originate in _____

Answer 1

bone marrow

Question 2

T cells develop in

Answer 2

thymus

Question 3

recognition phase of adaptive immune response occurs in

Answer 3

lymph nodes
spleen
mucosal-associated lymphoid tissue (MALT)

Question 4

_____ are common within all secondary lymphoid organs (primary and secondary)

Answer 4

lymphoid follicles

Question 5

loose network of follicular dendritic cells

rich in naive B cells/memory B cells

Answer 5

primary lymphoid follicles

Question 6

after antigen stimulation

replication and differentiation

Answer 6

secondary lymphoid follicles

Question 7

FDC’s normal function is to catch and display _____ antigen to B cells with ____ affinity receptors

Answer 7

opsonized

high

Question 8

the opsonized invader comes to __________ and FDCs have receptors that bind to _____ or ______

Answer 8

secondary lymph organs
complement proteins
Fc region of antibodies

Question 9

Once a B cell is activated in a lymph node, the # of B cells can _______ every ____ hours; the proliferating B cells push aside other B cells and create a dark zone

Answer 9

double

6

Question 10

Some B cells become _____ and leave for ______

Answer 10

plasma cells

bone marrow

Question 11

_____ likely occurs in the dark zone and is dependent on T-cell-B cell interaction

Answer 11

class switching

Question 12

antigen can enter via ___ or ____ at various points, lymphocytes leave blood and enter lymph node via _____

Answer 12

blood
lymph
high endothelial venules

Question 13

surrounds lymph node

Answer 13

capsule

Question 14

where lymph first enters the node

Answer 14

subcapsular sinus

Question 15

beneath the subcortical sinus

Answer 15

cortex

Question 16

beneath the germinal centers

Answer 16

paracortex

Question 17

beneath the cortex and paracortex

Answer 17

medulla

Question 18

lymphocytes enter the node via ____ or _____

Answer 18

arteriole

incoming lymph

Question 19

____ in blood vessels are columnar and offer more room for passage of cells

Answer 19

HEV cells

Question 20

blood filter between artery and vein; at rest 5% of cardiac output goes through this organ

Answer 20

spleen

Question 21

it takes ____ mins for spleen to screen ALL blood in body

Answer 21

30 mins

Question 22

no _____ lymphatics bringing lymph to spleen; ____ live in the marginal sinuses

Answer 22

affarent

resident dendritic cells

Question 23

______ lymphatic vessel drain into the intestinal lymph trunks, which then enter cistern chuli of lymph trunks

Answer 23

efferent

Question 24

blood entering the spleen is diverted to _______, which is loaded with MACROPHAGES, blood must filter back to ______

Answer 24

marginal sinuses

splenic vein

Question 25

specific region where T cells hang out in spleen

Answer 25

periarteriolar lymphocyte sheath (PALS)

Question 26

specific region where B cells hang out in spleen

Answer 26

area btwn PALS and marginal sinuses

Question 27

_____ in spleen removes old RBCs and recycles iron; _____ is broken down into individual AA and _____ is broken down into bilirubin

Answer 27

red pulp
globin
heme

Question 28

MALT in the small intestine, specifically GALT; adults have about 200,000 of these

Answer 28

peyer’s pathces

Question 29

antigen entry into peyer’s patches

Answer 29

M cells

Question 30

easily accessible to microorganisms in the intestine
lack villi
lack mucus
enclose intestinal antigens in vesicles (endosomes)

Answer 30

M cells

Question 31

T cell area for spleen

Answer 31

PALS

Question 32

B cell area for spleen

Answer 32

lymphoid follicles

Question 33

part of spleen lined with macrophages

Answer 33

marginal sinus

Question 34

B cell area of lymph node

Answer 34

cortex

Question 35

T cell area of lymph node

Answer 35

paracortex

Question 36

part of lymph node lined with macrophages

Answer 36

subscapular/maginal sinus