Secondary Hypogonadism Flashcards
1
Q
define
A
this is normal testes with hypothalamic/pituitary dysfunction
2
Q
diagnosis
A
LH/FSH is low/inappropriately normal with low testosterone
3
Q
what is affected
A
spermatogenesis
testosterone
4
Q
congenital causes
A
Kallman’s syndrome (isolated hypogonadotrophic hypogonadism)
Prader-Willi syndrome (excess appetite and rapid weight gain, loss of GnRH stimulus leading to impaired sexual development)
5
Q
acquired causes
A
pituitary damage (tumours, infiltrative disease, infection- TB, apoplexy and head trauma) hyperprolactinaemia obesity diabetes medications (steroids, opioids) acute systemic illness eating disorders excessive exercise
6
Q
define Kallman’s syndrome
A
genetic disorder with GnRH deficiency and hyposmia/anosmia
7
Q
what is Kallman’s associated with?
A
unilateral renal agenesis
red/green colour blindness
cleft lip/palate
bimanual synkinesis
8
Q
can Kallman’s affect women
A
yes
9
Q
buzzword for Kallman’s
A
anosmia and isolated GnRH deficiency
